Low Dose Chest Computed Tomography (CT) Screening
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01180010 |
Recruitment Status :
Completed
First Posted : August 11, 2010
Last Update Posted : December 29, 2016
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease | Intervention/treatment |
---|---|
Hodgkin's Lymphoma | Procedure: Low Dose CT |
Study Type : | Observational |
Actual Enrollment : | 31 participants |
Observational Model: | Case-Only |
Time Perspective: | Prospective |
Official Title: | Low-Dose Chest CT for Lung Cancer Screening in Survivors of Hodgkin's Disease |
Study Start Date : | August 2010 |
Actual Primary Completion Date : | September 2015 |
Actual Study Completion Date : | September 2015 |

- Procedure: Low Dose CT
A chest CT uses special radiographic equipment using x-rays to capture images of the chest, and with the aid of a computer, processes the images to create cross-sectional pictures or "slices" of the areas of interest. The images can then be printed out or examined on a monitor. The CT scanner is a large unit with a hole running directly through its center, giving the appearance of a doughnut. During the scanning, patients will lie flat on their back on a table, and they are periodically asked to hold their breath. The table will first move through the scanner to determine the correct starting position. The rest of the scans are made as the table moves more slowly through the cavity in the scanner.
- Lung cancer detection rate using chest CT screening in patients at increased risk of lung cancer after Hodgkin's disease therapy. [ Time Frame: 5 years ]
- False-positive rates of using chest CT for lung cancer screening in this population. [ Time Frame: 5 years ]
- The stage distribution, clinical characteristics and pathologic features of the detected lung cancer [ Time Frame: 5 years ]
- The treatment and treatment outcome of lung cancer after Hodgkin's disease in a cohort of patients undergoing routine chest CT screening [ Time Frame: 5 years ]

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- 5 years or longer from initial Hodgkin's disease diagnosis
- Current age 18 or older
- Received mediastinal irradiation and/or alkylating-agent based chemotherapy
- Smoking history of 10-pack years or more, or current smoker
Exclusion Criteria:
- Patients with a history of lung cancer
- Patients currently receiving treatment for another cancer diagnosis (patients with another cancer, but currently disease-free and not receiving treatment are eligible)
- Patients with known diagnosis of any metastatic cancer
- Pregnant women. Female patients must: be at least one year post-menopausal, have had a hysterectomy, or have a serum pregnancy test to confirm that they are not pregnant. These measures must be taken in order to avoid doing a CT scan of a pregnant woman.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01180010
Canada, Ontario | |
University Health Network, Princess Margaret Hospital | |
Toronto, Ontario, Canada, M5G 2M9 |
Principal Investigator: | David Hodgson, MD | University Health Network, Princess Margaret Hospital |
Responsible Party: | University Health Network, Toronto |
ClinicalTrials.gov Identifier: | NCT01180010 |
Other Study ID Numbers: |
UHN REB 08-0294-CE |
First Posted: | August 11, 2010 Key Record Dates |
Last Update Posted: | December 29, 2016 |
Last Verified: | December 2016 |
Hodgkin's Lymphoma Lung Cancer Lung Nodule CT scan |
Hodgkin Disease Lymphoma Neoplasms by Histologic Type Neoplasms |
Lymphoproliferative Disorders Lymphatic Diseases Immunoproliferative Disorders Immune System Diseases |