Green Tea Anticancer Mechanisms in Smokers
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|ClinicalTrials.gov Identifier: NCT01162642|
Recruitment Status : Completed
First Posted : July 14, 2010
Last Update Posted : April 21, 2015
|Condition or disease||Intervention/treatment||Phase|
|Cancer||Dietary Supplement: Green Tea Other: Placebo||Not Applicable|
Green tea contains phytochemicals, especially flavonoids. Phytochemicals are not absolutely required for normal functions, but may confer health benefits such as antioxidant actions. One can live without phytochemicals, but one may live longer and better with them. The phytochemicals in tea have been proposed to inhibit cancer onset via several different mechanisms. An obvious question is: Can anti-cancer actions of green tea be duplicated by black tea, which in the USA, is consumed more than green tea? The question remains unanswered, and will not be addressed by this project since many questions about green tea have not been answered yet. The contents of both type teas overlap in flavonoids, but green tea has more of the agents thought to be most effective. For example, some of the research cited below uses the flavonoid epigallocatechin gallate. Green tea has 5 times more of this flavonoid than black tea.
This study has two purposes. First, a case will be made that green tea may have several anti-cancer mechanisms, but this contention is not well confirmed by human intervention studies. This case will be made by addressing four questions. Second, justification will be given for the choice of mechanisms to be examined in this project's human intervention.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||43 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Green Tea Anticancer Mechanisms in Smokers|
|Study Start Date :||June 2010|
|Actual Primary Completion Date :||August 2013|
|Actual Study Completion Date :||August 2013|
Experimental: Green Tea
4 cups daily of green tea for 6 weeks
Dietary Supplement: Green Tea
Green Tea 4 cups daily
Placebo Comparator: No Green Tea
4 cups daily of placebo tea for 6 weeks
4 cups placebo tea for 6 weeks
- Antioxidant effects of green tea versus placebo consumption. [ Time Frame: Measured at post treatment ]Examine antioxidant effects of green tea versus placebo by measuring scavenging of free radicals; tea flavonoids; inflammatory cell secretion; endogenous antioxidant glutathione.
- Non-antioxidant, cancer-relevant effects of green tea consumption [ Time Frame: Measured at pre-treatment and post treatment ]Examine non-antioxidant, cancer-relevant effects of green tea by measuring NF-kappaB inducing kinase; phosphorylation of cell signaling agents; tumor necrosis factor gene expression; lysyl oxidase enzyme; blockage of cancer cell proliferation.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01162642
|United States, Ohio|
|The Ohio State University|
|Columbus, Ohio, United States, 43210|
|Principal Investigator:||Philip Diaz, M.D.||Ohio State University|