Comparison of Bone Morphogenetic Protein-4 (BMP-4) and 7 Levels Between Control and Polycystic Ovarian Syndrome (PCOS) Patients.
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|ClinicalTrials.gov Identifier: NCT01162447|
Recruitment Status : Unknown
Verified February 2010 by V.K.V. American Hospital, Istanbul.
Recruitment status was: Enrolling by invitation
First Posted : July 14, 2010
Last Update Posted : July 14, 2010
|Condition or disease|
|Polycystic Ovarian Syndrome|
Female patients at ages 20-35 diagnosed with polycystic ovarian syndrome and age-matched healthy control subjects will be enrolled in this study.
Blood samples will be obtained at early follicular phase during doctor's visit from PCOS patients and control subjects.If the patient is amenorrheic at the time of visit, both random blood samples and another sample at early follicular phase after induction of withdrawal bleeding with progesterone.
Follicular fluids will be retrieved during oocyte pick-up procedure in patients undergoing assisted reproduction for PCOS and control IVF patients whose infertility is not PCO related.
Samples from ovaries will be collected at operation from PCOS patients and control subjects if they already undergo any gynecologic laparotomi operations.
Collected samples will be cultured for 7 days and BMP-4 and -7 levels will be measured in the culture fluid of the samples using ELISA method.
|Study Type :||Observational|
|Estimated Enrollment :||50 participants|
|Observational Model:||Case Control|
|Official Title:||Comparison of Bone Morphogenetic Protein-4 and -7 Levels (BMP-4 and 7) in the Serum, Ovarian Follicle Aspirates and Ovarian Organ Culture Supernatants Between Healthy Controls and Patients With Polycystic Ovarian Syndrome (PCOS).|
|Study Start Date :||February 2010|
|Estimated Primary Completion Date :||February 2011|
|Estimated Study Completion Date :||February 2011|
Healthy control subjects and patients with polycystic ovarian syndrome will be recruited for the study.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01162447
|American Hospital Women's Health Center|
|Istanbul, Turkey, 34365|
|Study Director:||Bulent Urman, MD||VKV American Hospital Women's Health center|