1,5-AG as a Marker of Postprandial Hyperglycemia and Glucose Variability in Well-controlled Type 2 Diabetes Mellitus
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|ClinicalTrials.gov Identifier: NCT01161797|
Recruitment Status : Completed
First Posted : July 14, 2010
Last Update Posted : September 30, 2010
|Condition or disease|
|Type 2 Diabetes Mellitus|
1,5-Anhydroglucitol (AG) is a glucose analogue present in the plasma of healthy subjects. Physiologically, the plasma levels of 1,5-AG are very stable and only a small quantity is excreted in the urine. It is competitively reabsorbed with glucose in the renal tubules. Therefore, in the hyperglycemic state where glycosuria is present, glucose competitively inhibits renal tubular reabsorption of 1,5-AG and consequently the plasma 1,5-AG levels decrease. When glycemia is normalized and glycosuria is resolved, 1,5-AG levels increase.
The usefulness of 1, 5-AG in reflecting glycemic excursions have been demonstrated in moderately controlled patients to some extent, although some studies reveal controversial results.
Therefore, the aim of this study was to evaluate the association of 1,5-AG and postprandial hyperglycemia determined using the Continuous Glucose Monitoring System (CGMS) in DM patients with HbA1C<7% and evaluate the usefulness of 1,5-AG as a marker of glycemic control compared to HbA1C and fructosamine.
|Study Type :||Observational|
|Actual Enrollment :||53 participants|
|Official Title:||Correlation Between 1,5-anhydroglucitol and Postprandial Hyperglycemia by Continuous Glucose Monitoring System and Clinical Usefulness of 1,5-anhydroglucitol in Well-controlled Diabetic Patients|
|Study Start Date :||February 2008|
|Actual Study Completion Date :||July 2010|
- postprandial hyperglycemia [ Time Frame: 3days ]
- glucose variability [ Time Frame: 3 days ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01161797
|Korea, Republic of|
|Kyunghee University Medical Center|
|Seoul, Korea, Republic of, 130-702|
|Study Director:||Jeong-taek Woo, MD, PhD||Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea|