COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Screening for Atrial Fibrillation, After Ischemic Stroke

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01160406
Recruitment Status : Completed
First Posted : July 12, 2010
Last Update Posted : June 27, 2011
Information provided by:
Karolinska Institutet

Brief Summary:

The aim of the study is to assess the incidence of patients suffering from ischemic stroke or transient ischemic attacks who have underlying asymptomatic paroxysmal atrial fibrillation.

Patients who have suffered an ischemic stroke or transient ischemic attack, without a history of atrial fibrillation, are planned to be included. Starting within 14 days of the ischemic stroke, participating patients are asked to perform 10 second ECG recordings using a handheld ECG device twice daily (mornings and evenings) during 30 days. These recordings are transmitted via telephone to a secure encrypted Internet site. Within these 30 days the participants also perform an ambulatory 24 hour Holter recording. Handheld ECG recordings are evaluated continuously. In case of atrial fibrillation the patient is informed and offered treatment with anti coagulant medication (Warfarin). The investigation is a comparison between 24 hour continuous ECG recordings and short intermittent ECG recordings twice daily over a longer time period to determine which method is the best to detect atrial fibrillation in this patient group.

Hypothesis: Short Intermittent ECG recordings over a longer time period is more efficient, compared with continuous 24 hour ECG recordings, in detecting silent paroxysmal AF in patients with an ischemic stroke and without a history of atrial fibrillation.

Condition or disease
Atrial Fibrillation Stroke

Layout table for study information
Study Type : Observational
Estimated Enrollment : 250 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Improving Screening for Silent Atrial Fibrillation, After Ischemic Stroke
Study Start Date : June 2007
Actual Primary Completion Date : November 2010
Actual Study Completion Date : November 2010

Resource links provided by the National Library of Medicine

ischemic stroke, no atrial fibrillation
Patients who have suffered ischemic stroke or transient ischemic attack without known atrial fibrillation

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients from hospital strokewards.

Inclusion Criteria:

  • No previously diagnosed atrial fibrillation.
  • Acute ischemic stroke or transient ischemic attack verified by computed tomography or clinical diagnosis using the National Institute of Health Stroke Score within 14 days of enrollment.
  • Ability to understand study instructions both verbal and written.
  • Ability to perform and transmit ECG recordings according to study design.

Exclusion Criteria:

  • Previously diagnosed atrial fibrillation.
  • Hemorrhagic stroke
  • Low compliance
  • Pacemaker carrier

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01160406

Layout table for location information
Halmstad hospital
Halmstad, Halland, Sweden, 30180
South hospital
Stockholm, Sweden, 11883
Danderyds hospital AB
Stockholm, Sweden, 18288
Sponsors and Collaborators
Karolinska Institutet
Layout table for investigator information
Study Director: Mårten Rosenqvist, M.D.Ph.D. Karolinska Institutet
Layout table for additonal information
Responsible Party: Mårten Rosenqvist M.D. Ph.D., Karolinska Institutet Identifier: NCT01160406    
Other Study ID Numbers: KI-DSAB-2010
First Posted: July 12, 2010    Key Record Dates
Last Update Posted: June 27, 2011
Last Verified: June 2011
Keywords provided by Karolinska Institutet:
silent paroxysmal atrial fibrillation
tele ECG
Additional relevant MeSH terms:
Layout table for MeSH terms
Atrial Fibrillation
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Arrhythmias, Cardiac
Heart Diseases
Pathologic Processes