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Correlation Between Various Adipokines and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG) (18FDG-PET)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01150006
Recruitment Status : Completed
First Posted : June 24, 2010
Last Update Posted : June 29, 2010
Information provided by:
Korea University

Brief Summary:
The inflammatory state and composition of atherosclerotic plaques are considered the main contributing factors responsible for acute cardiovascular events, rather than the degree of stenosis. Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging technique to identify the inflammatory state of atherosclerotic plaque. Recently, a few clinical studies showed that circulating A-FABP level had a close relation with the development of atherosclerosis in human. Therefore, in the present study, the investigators examined the relationship between circulating A-FABP and vascular inflammation of carotid arteries measured using FDG-PET in healthy male subjects.

Condition or disease Intervention/treatment
Atherosclerosis Other: Cross sectional study

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Study Type : Observational
Actual Enrollment : 90 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Correlation Between Various Adipokines and Vascular Inflammation Measured by 18FDG-PET In Healthy Male Subjects
Study Start Date : April 2010
Actual Primary Completion Date : June 2010
Actual Study Completion Date : June 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Atherosclerosis

Group/Cohort Intervention/treatment
Healthy male participants Other: Cross sectional study
This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting

Primary Outcome Measures :
  1. Vascular inflammation in carotid arterial wall, represented as the target-to-background ratio (TBR), using FDG-PET [ Time Frame: 12 weeks ]

Secondary Outcome Measures :
  1. Circulating serum A-FABP levels [ Time Frame: 12 weeks ]
  2. Circulating serum leptin levels [ Time Frame: 12weeks ]
  3. Circulating serum adiponectin levels [ Time Frame: 12 weeks ]
  4. Carotid intima-media thickness levels measured using ultrasonography [ Time Frame: 12 weeks ]

Biospecimen Retention:   Samples Without DNA
whole blood, plasma, serum

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy male participats who underwent a medical health check in the health promotion center in Korea Guro University

Inclusion Criteria:

  • Healthy male volunteers for visiting routine medical check in our clinic

Exclusion Criteria:

  • History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
  • Diabetes
  • Hypertension
  • Malignancy
  • Severe renal or hepatic disease
  • Subjects taking medications that might affect inflammation such as NSIAD and statin

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01150006

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Korea, Republic of
Hye Jin Yoo
Seoul, Korea, Republic of, 152-703
Sponsors and Collaborators
Korea University
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Principal Investigator: Kyung Mook Choi, MD.PhD Korea University

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Responsible Party: Name/Official Title: Kyung Mook Choi, Korea University Identifier: NCT01150006     History of Changes
Other Study ID Numbers: PET_Adipokines
First Posted: June 24, 2010    Key Record Dates
Last Update Posted: June 29, 2010
Last Verified: April 2010
Keywords provided by Korea University:
vascular inflammation
adipocyte fatty acid binding protein
Additional relevant MeSH terms:
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Pathologic Processes
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Fluorodeoxyglucose F18
Molecular Mechanisms of Pharmacological Action