Evaluation of Cissus Verticillata L. Infusion in Controlling Type 2 Diabetes
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|ClinicalTrials.gov Identifier: NCT01145534|
Recruitment Status : Completed
First Posted : June 16, 2010
Last Update Posted : November 9, 2011
|Condition or disease||Intervention/treatment||Phase|
|Diabetes||Drug: glibenclamide Other: medicinal plant infusion||Phase 1 Phase 2|
Type 2 diabetes mellitus is regarded as one of the most prevalent disease of the adult population. In many developing countries, this condition is regarded as major public health problem. Type 2 diabetes is a metabolic disorder characterized by high blood glucose related with a condition of insulin resistance and relative insulin deficiency. As Diabetes progresses, medications are necessary to control glucose levels.
The aim of this study was to investigate whether the infusion of a medicinal plant (Cissus verticillata L.) would be as effective as a regular drug (glibenclamide) in reducing glucose levels in blood and saliva of type 2 Diabetes patients. Several medicinal plants have been used as potential medication for controlling glucose levels in Diabetes patients. Few studies have explored this effect related to Cissus verticillata L.infusion, though it has been indicated by folk medicine of some Latin American countries.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||15 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Phase 1 Study for Testing Efficacy of Cissus Verticillata L Infusion in Controlling Glucose Concentration|
|Study Start Date :||January 2009|
|Actual Primary Completion Date :||August 2009|
|Actual Study Completion Date :||October 2009|
Active Comparator: Glibenclamide
Patients used 5 mg glibenclamide daily for 60 days
5 mg as pills, taken daily during the morning for 60 days
Other Name: Glibenclamida, Legrand GE
Patients ingested the infusion of Cissus verticillata L. prepared as 1 g in 150 mL of hot water for 10 min. This was done daily for 60 days
Other: medicinal plant infusion
INfusion fo Cissus verticillata L., 1 g in 150 mL water, ingested daily for 60 days.
Other Name: popular plant name: Insulina
- blood glucose [ Time Frame: 60 days ]Blood glucose was measured using a Gluco Dr. Plus (AGM-3000) Blood Glucose Monitoring System.
- Salivary glucose level [ Time Frame: 60 days ]The level of glucose in saliva was measured in laboratory after colleting non-stimulated saliva in test tubes.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01145534
|Centro de Especialidades Odontologicas|
|Patos, Paraiba, Brazil, 58700-020|
|Study Chair:||Fabio C Sampaio, PhD||Federal University fo Paraiba|