Leukocyte Dysfunction in Diabetic Patients.
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|ClinicalTrials.gov Identifier: NCT01144520|
Recruitment Status : Unknown
Verified March 2018 by Sashwati Roy, Ohio State University.
Recruitment status was: Active, not recruiting
First Posted : June 15, 2010
Last Update Posted : March 20, 2018
|Condition or disease|
|Diabetes Mellitus, Type 2|
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Official Title:||Leukocyte Dysfunction in Diabetic Patients.|
|Study Start Date :||March 2010|
|Estimated Primary Completion Date :||December 2018|
|Estimated Study Completion Date :||December 2018|
Healthy subjects that do not have diabetes
Type II Diabetes (HbA1c <7 or 7%)
Subject that have Type II Diabetes with good glucose control with glycated hemoglobin (HbA1c <7 or 7%)
Type II Diabetes (HbA1c between 7.1-9)
Subjects with Type II Diabetes with moderate glucose control (HbA1c between 7.1-9)
Type II Diabetes (HbA1c >9%)
Subjects with Type II Diabetes with poor glucose control (HbA1c >9%)
- Ex vivo leukocyte function by measuring ROS production [ Time Frame: immediately after blood draw ]After blood draw monocytes are separated from whole blood and production of oxidants by these cells
- Ex vivo NADPH oxidase gene and protein expression [ Time Frame: After blood draw ]Gene and protein expressions are measured using Western blot and real time PCR.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01144520
|United States, Ohio|
|Ohio State University Comprehensive Wound Center|
|Columbus, Ohio, United States, 43221|
|Principal Investigator:||Roy Sashwati, MS, PhD||Ohio State University Dept of Surgery|