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Trial record 1 of 1 for:    "Cohort of Swedish Men"
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Cohort of Swedish Men (COSM)

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ClinicalTrials.gov Identifier: NCT01127711
Recruitment Status : Completed
First Posted : May 21, 2010
Last Update Posted : February 28, 2014
Sponsor:
Information provided by (Responsible Party):
Alicja Wolk, Karolinska Institutet

Study Description
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Brief Summary:
The Cohort of Swedish Men began in 1997, when all men born between 1918 and 1952 and residing in two counties in central Sweden received a questionnaire including about 350 items concerning diet and other lifestyle factors. A second questionnaire was sent out in 2008-09.

Condition or disease
Cancers Cardiovascular Diseases Cataract Gastrointestinal Diseases Osteoporosis Fractures

Detailed Description:

The Cohort of Swedish Men was established in 1997, when all men born between 1918 and 1952 and residing in Västmanland and Örebro counties in central Sweden received a questionnaire concerning diet and other lifestyle factors. Of the 100,303 eligible men, 48,850 (49%) responded to the questionnaire. The questionnaire included items about diet, physical activity, medical history, and lifestyle factors such as cigarette smoking history and use of dietary supplements.

During 2008-09, the exposure information was updated and extended by sending out two new questionnaires - one questionnaire on health including several signs of symptoms, sleeping, social relations etc (2008) and one on diet, dietary supplement use, and lifestyle factors (2009). Majority of questions in the questionnaires have been validated.

Incident cases of cancer are ascertained by record linkages of the study population with the National Swedish Cancer Register and the Regional Cancer Registers. Cardiovascular and other diseases as well as surgeries and causes of death are identified by linkage to the National Inpatient and other registries at the Swedish Board of Health and Welfare. Ascertainment of cancer cases and other diseases is almost 100% complete. Dates of deaths are ascertained through the Swedish Death Register (100% complete), and information on date of moving out of the study area is obtained by linkage with the Swedish Population Register.

Study Design
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Layout table for study information
Study Type : Observational
Actual Enrollment : 48850 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Cohort of Swedish Men
Study Start Date : September 1997
Actual Primary Completion Date : December 1997
Groups and Cohorts
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Outcome Measures
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Primary Outcome Measures :
  1. Prostate cancer [ Time Frame: 1997-2010 ]
  2. Pancreatic cancer [ Time Frame: 1997-2010 ]
  3. Stomach cancer [ Time Frame: 1997-2010 ]
  4. Cataract [ Time Frame: 1997-2010 ]
  5. LUTS (Lower urinary tract symptom) [ Time Frame: 1997-2010 ]
  6. Cardiovascular Diseases [ Time Frame: 1997-2010 ]
  7. Mortality [ Time Frame: 1997-2010 ]
  8. Colorectal Cancer [ Time Frame: 1997-2010 ]
  9. Bladder cancer [ Time Frame: 1997-2010 ]
  10. Fractures, hip fractures [ Time Frame: 1997-2014 ]

Biospecimen Retention:   Samples With DNA
Saliva Blood

Eligibility Criteria
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Information from the National Library of Medicine

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Layout table for eligibility information
Ages Eligible for Study:   45 Years to 79 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Men born between 1918 and 1952, living in central Sweden (Örebro and Västmanlands counties)
Criteria

Inclusion Criteria:

  • All men born between 1918 and 1952, living in central Sweden

Exclusion Criteria:

  • None
Contacts and Locations
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No Contacts or Locations Provided
More Information
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Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
Additional Information:

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Layout table for additonal information
Responsible Party: Alicja Wolk, Professor, Karolinska Institutet
ClinicalTrials.gov Identifier: NCT01127711    
Other Study ID Numbers: 1706/2010-631-2
First Posted: May 21, 2010    Key Record Dates
Last Update Posted: February 28, 2014
Last Verified: February 2014
Additional relevant MeSH terms:
Layout table for MeSH terms
Osteoporosis
Gastrointestinal Diseases
Digestive System Diseases
Cataract
Cardiovascular Diseases
Bone Diseases, Metabolic
 Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases
Lens Diseases
Eye Diseases