Inflammatory Cytokines Profile in Individuals Subjected to Surgical Procedures Using Propofol or Isoflurane
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01111227|
Recruitment Status : Completed
First Posted : April 27, 2010
Last Update Posted : April 27, 2010
|Condition or disease||Intervention/treatment||Phase|
|Patients in Good Health||Drug: Propofol and isoflurane||Phase 4|
Twenty ASA-I patients, subjected to otorhinolaryngology surgery, were randomly allocated in one group to receive anesthesia with isoflurane 1 MAC (minimum alveolar concentration) (n = 20). Other group with twenty ASA-I patients received propofol 2 to 4 microgram mL-1 (n = 20).
Fentanyl 5 mg kg-1 and rocuronium bromide 0.6 mg kg-1 were also administered to all patients. Venous blood (10 mL) was collected from each patient at each of the following times: before the beginning of surgery and anesthesia (T1), 2 h after the beginning of surgery (T2), and on the day after the anesthetic-surgical procedure (T3).
Plasma concentrations of interleukins IL-1beta, IL-6, IL-8, IL-10 and IL-12 and tumor necrosis factor (TNF-alpha) were measured in each sample through flow cytometry technique by using the method Cytometric Bead Array (CBA). Venous blood samples from fifteen volunteers not subjected to stress were also collected as control, and the same cytokines were measured.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Supportive Care|
|Official Title:||Inflammatory Cytokines Profile in Individuals Subjected to Surgical Procedures Using Propofol or Isoflurane.|
|Study Start Date :||March 2008|
|Actual Primary Completion Date :||December 2009|
|Actual Study Completion Date :||December 2009|
- Drug: Propofol and isoflurane
Comparison of two anesthetic drugsOther Names:
- Evaluation of cytokines profile [ Time Frame: Before surgery and anesthesia, 2h after anesthesia and at the following day of the surgery ]
- Evaluation of pro and anti-inflammatory cytokines [ Time Frame: before surgery and anesthesia, 2h after anesthesia and at the following day of the surgery ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01111227
|Botucatu Medical School, UNESP|
|Botucatu, São Paulo, Brazil, 18603-970|
|Principal Investigator:||Marina Á Mazoti, MsC||Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP|