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Effects Of Unilateral Vibration On Contralateral Forearm Muscle Activity (BMRR3)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01097122
Recruitment Status : Completed
First Posted : April 1, 2010
Last Update Posted : February 27, 2012
Information provided by (Responsible Party):
ILHAN KARACAN, Vakif Gureba Training and Research Hospital

Brief Summary:

This study hypothesize that radius subjecting to mechanical loading may affect excitability of alpha motor neuron innervating muscle, based on its bone mineral density or bone mineral content.

A total of 80 voluntaries are planned to include in this study. Vibration will be applied the right forearm. Muscle electrical activity will be measured on ipsilateral and contralateral flexor carpi radialis (FCR) muscle at rest as EMGrms by surface electromyography (EMG). The rest-EMGrms will be measured at before and during vibration. An increase in muscle electrical activity at rest indicates an increase in motor neuron pool activation. The right distal radius bone mineral content (BMC) and density will be measured by dual energy X-ray absorptiometry (DXA).

The right radius bone mineral density (BMD) and BMC will be evaluated by bone densitometer (GE-LUNAR DPX PRO).

Motor unit potentials will be measured by electromyography at left flexor carpi radialis. Neurotrac ETS device will be used.

Condition or disease Intervention/treatment Phase
Osteoporosis Excitability Procedure: Forearm vibration Not Applicable

Detailed Description:

A functional cooperation exists between bones and skeletal muscles. Bones work together with muscles as a simple mechanical lever system to produce body movement. One of the important functions of bones is to exert resistance against gravity in order to carry the body. In order to carry out their mechanical functions, bones need to have considerable resistance to deformation under load. It is well-known that muscle activity (i.e., exercises) improves the resistance of bone to mechanical loading, and that it is also important for treating and preventing osteoporosis. Resistance and impact training have been shown to induce bone formation and/or prevent bone resorption. Skeletal muscles have positive effects on bone structure and function. Can bones have an effect on muscle activity? There is only one study about the effect of bones on muscles. In this study, it was shown that bones may affect muscle strength gain in healthy young adult males.

Vibration has a strong osteogenic effect. Vibration-induced bone formation is neuronally regulated. Vibration can also effectively enhance muscle strength and power. Previous studies have shown that vibration increases muscle electromyographic (EMG) activity. But, it has not been reported whether bone has an effect on the increase in muscle EMG activity caused by vibration or not. The aim of this study was to determine whether radius bone exposed to cyclic mechanical loading affects muscle electrical activity of contralateral untrained m. flexor carpi radialis in healthy adult volunteers.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 90 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Effects Of Unilateral Forearm Vibration On Electrical Activity Of Untrained Contralateral Forearm Muscle
Study Start Date : March 2010
Actual Primary Completion Date : June 2010
Actual Study Completion Date : July 2010

Arm Intervention/treatment
Experimental: Healthy young adult subjects
Forearm vibration will be applied in healthy young adult subjects
Procedure: Forearm vibration
Mechanical loading with forearm vibration will be applied right radius in all groups
Other Name: Cyclic mechanical loading

Primary Outcome Measures :
  1. Changes in rest muscle electrical activity in the contralateral untrained flexor carpi radialis during the right forearm vibration [ Time Frame: 2 or 3 weeks ]
    Rest muscle electrical activity changes will be examined in the contralateral untrained flexor carpi radialis during the right forearm vibration

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy subjects
  • Right handed
  • Young adult women and men

Exclusion Criteria:

  • secondary osteoporosis
  • neuropathy (central or peripheral)
  • myopathy
  • systemic diseases (arthritis, endocrine-metabolic diseases, bone diseases)
  • professional sportswoman/sportsman
  • subjects doing regular sports activities
  • tendinopathy
  • amputee, endoprosthesis, metal implants

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01097122

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Vakif Gureba Training & Research Hospital
İstanbul, Turkey, 34000
Sponsors and Collaborators
Vakif Gureba Training and Research Hospital
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Study Chair: ILHAN KARACAN, MD Vakif Gureba Training & Research Hospital
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Responsible Party: ILHAN KARACAN, Vakif Gureba Training and Research Hospital Identifier: NCT01097122    
Other Study ID Numbers: VGEAH FTR-3
First Posted: April 1, 2010    Key Record Dates
Last Update Posted: February 27, 2012
Last Verified: February 2012
Keywords provided by ILHAN KARACAN, Vakif Gureba Training and Research Hospital:
motor neuron excitability
forearm vibration
mechanical loading
muscle electrical activity
Additional relevant MeSH terms:
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Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases