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Characterization of Aerosol Generation and Transport in the Human Lung

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ClinicalTrials.gov Identifier: NCT01095627
Recruitment Status : Completed
First Posted : March 30, 2010
Last Update Posted : February 9, 2011
Sponsor:
Information provided by:
Fraunhofer-Institute of Toxicology and Experimental Medicine

Brief Summary:
This study is aiming at evaluating whether the number and size of exhaled particles changes during the increase and decrease of bronchial constriction in subjects with mild intermittent asthma.

Condition or disease Intervention/treatment Phase
Asthma Other: Metacholine challenge Not Applicable

Detailed Description:
Particle emission demonstrates high reproducibility within subjects while between-subject-variability is large. Methacholine challenge in subjects with mild intermittent asthma will provide data from repetitive measurements in the same subject with variable airflow obstruction.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 10 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Characterization of Aerosol Generation and Transport in the Human Lung of Subjects With Mild Intermittent Allergic Asthma Before and After Methacholine Challenge
Study Start Date : March 2010
Actual Primary Completion Date : June 2010
Actual Study Completion Date : June 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma

Arm Intervention/treatment
Metacholine Challenge
Exhaled breath analysis following metacholine challenge
Other: Metacholine challenge
Exhaled breath analysis following metacholine challenge




Primary Outcome Measures :
  1. Exhaled breath analysis [ Time Frame: Within one day ]
    In ten subjects with mild intermittent allergic asthma particles in exhaled breath will be analyzed for their number and size in a time dependent manner before and after induction of bronchial obstruction by methacholine challenge.



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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Male or female subjects, aged 18 to 65 years.
  2. Physician diagnosis of mild intermittent allergic asthma (GINA I according to GINA guidelines9).
  3. Normal lung function parameters at baseline (FEV1 > 80 % of predicted)
  4. Non smoker or smokers with a history of less than 10 pack years with no smoking in the last 12 months.
  5. Able and willing to give written informed consent
  6. Women will be considered for inclusion if they are:

not pregnant, as confirmed by pregnancy test, and not nursing of non-child bearing potential (i.e. physiologically incapable of becoming pregnant, including any female who is pre-menarchial or post-menopausal, with documented proof of hysterectomy or tubal ligation, or meet clinical criteria for menopause and has been amenorrhoeic for more than 1 year prior to the screening visit) of childbearing potential and using a highly effective method of contraception during the entire study (vasectomized partner, sexual abstinence - the lifestyle of the female should be such that there is complete abstinence from intercourse from two weeks prior to the study until at least 72 hours after the end of the study -, implants, injectables, combined oral contraceptives, hormonal IUDs, or double-barrier methods, i.e. any double combination of IUD, condom with spermicidal gel, diaphragm, sponge, and cervical cap)

• Available to complete all study measurements

Exclusion Criteria:

  1. History of lower respiratory tract infection four weeks prior to the informed consent visit.
  2. Past or present disease, which as judged by the investigator, may affect the outcome of this study. These diseases include, but are not limited to, cardiovascular disease, malignancy, hepatic disease, renal disease, hematological disease, neurological disease, endocrine disease or pulmonary disease (including but not confined to chronic bronchitis, emphysema, tuberculosis, bronchiectasis or cystic fibrosis).
  3. Regular intake of any prescribed or over the counter medication. Exceptions include paracetamol for pain relief, oral contraceptive medication, hormonal replacement therapy, dietary and vitamin supplements, and short acting beta mimetics (SABA) on as needed basis.
  4. Use of anti-inflammatory medication including systemic or inhaled corticosteroid within the last four weeks.
  5. Any history of life-threatening asthma, defined as an asthma episode that required intubation and/or was associated with hypercapnea, respiratory arrest or hypoxic seizures.
  6. Conditions or factors, which would make the subject unlikely to be able to undergo methacholine challenge.
  7. Conditions which provide a contraindication for methacholine challenge testing such as uncontrolled arterial hypertension, known aortic aneurysm, myocardial infarction or stroke within three months prior to study, current use of cholinesterase inhibitor medication.
  8. Inability to perform acceptable-quality spirometry.
  9. History of drug or alcohol abuse.
  10. Participation in another clinical trial 30 days prior to enrolment.
  11. Suspected inability to understand the protocol requirements, instructions and study-related restrictions, the nature, scope, and possible consequences of the study.
  12. Risk of non-compliance with study procedures.

Additional Information:
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Responsible Party: Prof. Dr. Norbert Krug, Fraunhofer-Institute of Toxicology and Experimental Medicine
ClinicalTrials.gov Identifier: NCT01095627     History of Changes
Other Study ID Numbers: 10/04 AEROB
First Posted: March 30, 2010    Key Record Dates
Last Update Posted: February 9, 2011
Last Verified: February 2011

Additional relevant MeSH terms:
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Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases