Periodontal Infection and Systemic Inflammation in Renal Patients (PeriRen)
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|ClinicalTrials.gov Identifier: NCT01094639|
Recruitment Status : Completed
First Posted : March 29, 2010
Last Update Posted : October 25, 2016
|Condition or disease||Intervention/treatment||Phase|
|Periodontitis Chronic Kidney Disease||Procedure: Scaling root planing Procedure: Supragingival Prophylaxis||Not Applicable|
The main goal of this project was to explore the contribution of chronic periodontitis to systemic inflammation in Chronic Kidney Disease (CKD). To achieve this goal, the project had two specific objectives:
- a) To compare the prevalence of periodontal infection between CKD and non-CKD populations and b) to explore the association between the presence of periodontal infection and the uremic status of CKD patients.
- a) To assess the levels of systemic inflammatory markers, IL-6 and CRP in the presence or absence of periodontal infection in CKD and b) to compare the serum IL-6 and CRP levels in response to periodontal intervention.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||52 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||Periodontal Infection and Systemic Inflammation in Renal Patients|
|Study Start Date :||August 2009|
|Actual Primary Completion Date :||July 2015|
|Actual Study Completion Date :||August 2015|
Placebo Comparator: Supragingival prophylaxis
Procedure: Supragingival Prophylaxis
Active Comparator: Scaling root planing
Procedure: Scaling root planing
Deep gum cleaning with local anesthesia
- Serum Interleukin-6 (IL-6) and C-reactive protein (CRP) levels [ Time Frame: 2 months ]IL-6 and CRP are markers of systemic inflammation and may improve at the end of gum treatment.
- Changes in periodontal (gum) clinical presentation and status [ Time Frame: 2 months ]For the secondary outcome, periodontal variables such as bleeding on probing, probing depth (the depth of the gum sulcus around the tooth), and bacterial plaque score will be evaluated to assess the effectiveness of the intervention and the compliance of the patients
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01094639
|United States, Connecticut|
|University of Connecticut Health Center|
|Farmington, Connecticut, United States, 06030-1710|
|Principal Investigator:||Efthimia Ioannidou, DDS, MDS||UConn Health|