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Activities for Cognitive Enhancement of Seniors (ACE-Seniors)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01094509
Recruitment Status : Completed
First Posted : March 29, 2010
Last Update Posted : November 20, 2014
National Institute on Aging (NIA)
Information provided by (Responsible Party):
Victor W. Henderson, Stanford University

Brief Summary:
Cognitive aging and cognitive decline are important public health concerns in an aging US population. The investigators will conduct a randomized controlled trail among healthy older adults to assess effects of several innovative activities on remediation of age-related cognitive decline.

Condition or disease Intervention/treatment Phase
Aging Behavioral: Tai Chi Behavioral: Guided autobiography Behavioral: Qigong Behavioral: Successful aging Behavioral: Combination Behavioral: Comparison Not Applicable

Detailed Description:
ACE-Seniors is designed as a single-site trial of four randomly assigned interventions, Tai Chi exercise, autobiographical writing, both Tai Chi and autobiography (dual intervention), and general health education. Participants are relatively healthy adults aged 70 years or older, who are not regular practitioners of Tai Chi or regular writers. They are without medical or neurological disorders that would substantially limit the ability to participate in study interventions, without dementia or mild cognitive impairment, relatively sedentary, able to walk unassisted, and able to score 4 or better on the Short Physical Performance Battery. Interventions are administered over a 6 month period of time, with similar exposure times among the four groups. The prespecified primary endpoint is derived from a composite neuropsychological measure, based on three tests of executive function and three tests of episodic memory. The planned sample size is 96 (24 per group). Intention-to-treat analysis will include all eligible participants who complete baseline assessments.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 175 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Tai Chi and Guided Autobiography for Remediation of Age-related Cognitive Decline
Study Start Date : March 2010
Actual Primary Completion Date : July 2012
Actual Study Completion Date : December 2013

Arm Intervention/treatment
Experimental: Tai Chi
Tai Chi exercises
Behavioral: Tai Chi
Tai Chi classes and exercises

Experimental: Guided autobiography
Autobiographical writing during class sessions and at home
Behavioral: Guided autobiography
Autobiographical writing in class and at home

Experimental: Qigong
Qigong exercises (exploratory, not part of the original protocol, added to gain experience with this intervention)
Behavioral: Qigong
Qigong classes and exercises (exploratory)

Active Comparator: Successful aging
Seminars on the theme of successful aging
Behavioral: Successful aging
Seminar series on the theme of successful aging

Experimental: Combination
Combination of Tai Chi exercises and autobiographical writing
Behavioral: Combination
Combination of Tai Chi exercises and autobiographical writing

Placebo Comparator: Comparison
No assigned experimental activity (exploratory, not part of the original protocol, added to gain experience with a placebo comparator)
Behavioral: Comparison
No assigned behavioral activity (exploratory)

Primary Outcome Measures :
  1. Cognitive (executive function and episodic memory) [ Time Frame: 6 and 12 months ]

Secondary Outcome Measures :
  1. Other cognitive measures [ Time Frame: 6 and 12 months ]
  2. Physical performance and other non-cognitive measures [ Time Frame: 6 and 12 months ]
  3. Adherence and retention [ Time Frame: 6 and 12 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   70 Years and older   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • 70 years of age or older.
  • No other household member already enrolled.
  • In reasonably good health: no serious cognitive problem; free of any condition that would limit your ability to participate in Tai Chi classes (a moderate intensity exercise), in Qigong exercises, in a writing program, or in a seminar series.
  • Not presently engaged in a regular exercise program; not presently engaged in Tai Chi Qigong or another form of Eastern exercise; and not a regular writer.
  • Not now engaged in research to enhance cognitive skills.
  • Willing to travel to Stanford for ACE-Seniors program classes. Planning to be in the area during most of the coming year;
  • Willing to be assigned randomly (by chance) to one of the ACE-Senior activities.

Exclusion Criteria:

  • Failure to meet inclusion criteria.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01094509

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United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
National Institute on Aging (NIA)
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Principal Investigator: Dr Victor Henderson Stanford University
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Responsible Party: Victor W. Henderson, Professor, Stanford University Identifier: NCT01094509    
Other Study ID Numbers: SU-02042010-4903
R01AG034639 ( U.S. NIH Grant/Contract )
First Posted: March 29, 2010    Key Record Dates
Last Update Posted: November 20, 2014
Last Verified: November 2014