Troponin T as Risk Stratification Tool in Peripheral Arterial Occlusive Disease
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ClinicalTrials.gov Identifier: NCT01087385
Recruitment Status :
First Posted : March 16, 2010
Last Update Posted : April 15, 2015
University Heart Center Freiburg - Bad Krozingen
Johann Wolfgang Goethe University Hospital
Information provided by (Responsible Party):
Birgit Linnemann, University Heart Center Freiburg - Bad Krozingen
Study hypothesis: elevated Troponin T is a marker of increased mortality in patients with peripheral arterial occlusive disease (PAOD).
Condition or disease
Peripheral Arterial Occlusive Disease
Troponin T and I are established risk markers in patients with acute coronary syndrome. Only recently, troponin I was found to be elevated in patients with acute critical limb ischaemia. In another study, troponin I was associated with a higher mortality in patients with chronic critical limb ischaemia followed over two years. In a longitudinal study design we intend to follow all patients that were treated for symptomatic PAOD (Fontaine stages II-IV) from 01/2007 to 12/2007 in our department of angiology. Main outcome parameters are death and the occurrence of major vascular events and revascularization procedures during follow-up.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
patients with peripheral arterial occlusive disease (Fontaine stages II-IV)
symptomatic peripheral arterial occlusive disease
aged >/= 18 years
unstable angina or acute coronary syndrome < 14 days
percutaneous coronary intervention < 14 days
other interventions or disease associated with troponin T release (i.e., acute pulmonary embolism, aortic dissection, heart valve replacement, acute heart failure, non-ischemic cardiomyopathy, heart surgery, thoracic trauma, endocarditis, myocarditis