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Effect of Adding Sufentanil to Epidural Ropivacaine on Perioperative Metabolic and Stress Responses in Combined General/Epidural Anaesthesia for Geriatric Radical Retropubic Prostatectomy

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ClinicalTrials.gov Identifier: NCT01086956
Recruitment Status : Completed
First Posted : March 15, 2010
Last Update Posted : November 11, 2010
Sponsor:
Information provided by:
Yonsei University

Study Description
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Brief Summary:
The purpose of this study is to compare metabolic and stress responses in combined general/epidural anesthesia in geriatric cancer patients.

Condition or disease Intervention/treatment Phase
Prostatic Cancer Drug: epidural infusion of saline, ropivecaine, or ropivacaine and sufentanil Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Primary Purpose: Diagnostic
Official Title: Effect of Adding Sufentanil to Epidural Ropivacaine on Perioperative Metabolic and Stress Responses in Combined General/Epidural Anaesthesia for Geriatric Radical Retropubic Prostatectomy
Study Start Date : September 2008
Actual Primary Completion Date : December 2009
Actual Study Completion Date : December 2009

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Arms and Interventions
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Outcome Measures
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Primary Outcome Measures :
  1. plasma glucose, insulin, cortisol, epinephrine, norepinephrine, prolactin [ Time Frame: from preoperative baseline to postoperative 24 hours ]

Eligibility Criteria
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Ages Eligible for Study:   65 Years and older   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • elective RRP for prostatic cancer scheduled in the morning (9-11 a.m.)
  • patients aged more than 65 years
  • ASA physical status I or II
  • absence of contraindications to epidural approach
  • absence of a history of chronic pain or opioid medication

Exclusion Criteria:

  • contraindication to epidural catheterization
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01086956


Locations
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Korea, Republic of
Severance Hospital
Seoul, Korea, Republic of
Sponsors and Collaborators
Yonsei University
More Information
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Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Kil Hae Keum, Yonsei University College of Medicine, Seoul, Republic of Korea
ClinicalTrials.gov Identifier: NCT01086956    
Other Study ID Numbers: 4-2008-0319
First Posted: March 15, 2010    Key Record Dates
Last Update Posted: November 11, 2010
Last Verified: November 2010
Keywords provided by Yonsei University:
patients of prostatic cancer aged more than 65 years
Additional relevant MeSH terms:
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Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Neoplasms
Prostatic Diseases
Sufentanil
Ropivacaine
Anesthetics, Local
Anesthetics
 Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Analgesics, Opioid
Narcotics
Analgesics
Adjuvants, Anesthesia
Anesthetics, Intravenous
Anesthetics, General