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Genetics of Obesity in Chinese Youngs (GOCY)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT01084967
Recruitment Status : Recruiting
First Posted : March 11, 2010
Last Update Posted : April 26, 2016
Information provided by (Responsible Party):
Guang Ning, Shanghai Jiao Tong University School of Medicine

Brief Summary:
The purpose of this study is to explore the pathogenesis and genetic susceptibility of obese subjects,providing a convincing argument for further treatment of obesity and metabolic syndrome.

Condition or disease
Obesity Metabolic Syndrome

Detailed Description:

Obesity has become a major worldwide challenge to public health, owing to an interaction between the obesogenic environment and a strong genetic contribution.Previous studies found that genetic factors determine 40%-70% of obese phenotype.Under such circumstances, the screening of obesity susceptibility gene is particularly important for society or family to take measures to prevent obesity.

Recent extensive genome-wide association studies(GWASs) have identified numerous single nucleotide polymorphisms associated with obesity,but these loci together account for only a small fraction of the known heritable component.Two studies in 2010 Nature,for the first time, put rare copy number variation (CNV)in association with severe early-onset obesity.Their significance lie not only in the discovery of the pathogenic genes of severe early-onset obesity but,more importantly,in providing new strategies for finding out genes that cause complex diseases.

Obese patients and healthy lean controls proved by a series of blood biochemical examinations will be enrolled in this study.The present study intends to use the techniques such as enzyme-linked immunosorbent assay, real-time fluorescence quantitative PCR,gene chip,construction of viral vectors,transfection,taking advantage of the established database,by means of serum assays and functional tests, associate copy number variation with obesity phenotype to explain the root cause of obesity.Meanwhile biomarkers and genetic risk factors will be evaluated in the study subjects.

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Study Type : Observational
Estimated Enrollment : 3000 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Study of Clinical Characteristics and Genetic Susceptibility in Chinese Obese Youngs
Study Start Date : March 2009
Estimated Primary Completion Date : April 2021
Estimated Study Completion Date : April 2021

Resource links provided by the National Library of Medicine

Healthy lean control group
BMI:18.5-22.9kg/m2. Age:14-30 years old. To be proved normal by the examinations of liver and kidney function,blood lipids profile,fasting and postprandial plasma glucose, fasting insulin and HbA1c.
obesity group with BMI ≥30
obesity group 1500, lean healthy control group 1500

Biospecimen Retention:   Samples With DNA
Whole blood,fasting serum and morning urine

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   14 Years to 30 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The population from which cohorts will be selected include students, residents, staff, and/or faculty who are present on Shanghai Jiaotong University school of medicine, and surrounding areas.

Inclusion Criteria:

  • body mass index (BMI)≥ 30kg/m2
  • predominantly east China to minimize population stratification
  • willing and able to provide informed consent

Exclusion Criteria:

  • pregnancy/lactation
  • Cushing syndrome
  • Hypothyroidism
  • obesity caused by pituitary and hypothalamic lesions
  • drug related obesity
  • history of major psychiatric illness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01084967

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Contact: Guang Ning, MD.PhD 86-21-64370045 ext 665340
Contact: Jie Hong, PhD 86-21-64370045 ext 665345

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China, Shanghai
Shanghai Jiao Tong University School of Medicine Recruiting
Shanghai, Shanghai, China, 200025
Contact: Guang Ning, MD.PhD    86-21-64370045 ext 665340   
Contact: Jie Hong, PhD    86-21-64370045 ext 665345   
Principal Investigator: Guang Ning, MD.PhD         
Sponsors and Collaborators
Shanghai Jiao Tong University School of Medicine
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Principal Investigator: Guang Ning, MD.PhD Shanghai Jiao Tong University School of Medicine
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Responsible Party: Guang Ning, Director, Shanghai Jiao Tong University School of Medicine Identifier: NCT01084967    
Other Study ID Numbers: CCEMD008
First Posted: March 11, 2010    Key Record Dates
Last Update Posted: April 26, 2016
Last Verified: April 2016
Keywords provided by Guang Ning, Shanghai Jiao Tong University School of Medicine:
metabolic syndrome
genetic risk markers
copy number variation
Additional relevant MeSH terms:
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Metabolic Syndrome
Nutrition Disorders
Body Weight
Signs and Symptoms
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases