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Optimal End-Tidal (ET) Sevoflurane and Desflurane Concentration for Extubation of Supreme Laryngeal Mask Airway (LMA) in Adults

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01083953
Recruitment Status : Completed
First Posted : March 10, 2010
Last Update Posted : December 3, 2015
Malaysian Society of Anaesthesiologists
Information provided by (Responsible Party):
Cindy Thomas Joseph, University of Malaya

Brief Summary:

The purpose of this study is to determine the optimal volatile anaesthetic (sevoflurane and desflurane) to remove a Supreme LMA in adults in which there is minimal airway response.

Null hypothesis: there is no significant difference between the optimal end tidal concentration of sevoflurane and desflurane for Supreme LMA removal.

Condition or disease Intervention/treatment Phase
Airway Complications Drug: Sevoflurane Drug: Desflurane Not Applicable

Detailed Description:

The manufactures' instructions for removal of the LMA recommend waiting until protective reflexes have returned. However, the appropriate timing for removal remains controversial. A more frequent incidence of airway hyperreactivity and complications has been reported by some studies when the LMA was removed in the awake state versus the anesthetized state. Techniques that reduce the time from LMA removal to the return of protective airway reflexes would minimize the risk of aspiration, contamination, or airway obstruction.

With increasingly common use of Supreme LMA in anaesthetic practice, a safe and suitable depth for removal of the Supreme LMA requires research.

Thus the determination of the optimal end-tidal concentration of commonly used volatile agents ie. Sevoflurane and Desflurane for Supreme LMA removal requires research, both for patient safety and minimising anaesthetic costs in dealing with airway complications.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 54 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: Optimal End-Tidal Concentration of Sevoflurane and Desflurane for Removal of Supreme Laryngeal Mask Airway in Anaesthetized Adults
Study Start Date : November 2009
Actual Primary Completion Date : July 2010
Actual Study Completion Date : July 2010

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Sevoflurane
1 arm will receive sevoflurane at varying concentrations at which extubation is attempted according to the Dixon up and down method
Drug: Sevoflurane
Comparing the optimal end-tidal concentration sevoflurane and desflurane for LMA extubation

Experimental: Desflurane
1 arm will receive desflurane at varying end tidal concentration at which extubation will be attempted according to Dixon up and down method
Drug: Desflurane
Comparing the optimal end-tidal concentration sevoflurane and desflurane for LMA extubation

Primary Outcome Measures :
  1. Optimal end tidal concentration of sevoflurane/ desflurane [ Time Frame: 6 months ]

Secondary Outcome Measures :
  1. presence of airway response [ Time Frame: 10 mins after surgery ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 49 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. ASA 1-2 patients
  2. Age 18 - 49 years old
  3. Elective surgery of short duration ( < 2 hours ) which require local anaesthetic infiltration

Exclusion Criteria:

  1. Upper respiratory tract symptoms in the previous 10 days
  2. Risk of gastric oesophageal reflux or regurgitation
  3. Known or predicted difficult airway
  4. Poor dentition with high risk of damage
  5. BMI > 30 kg/m2
  6. Refusing to participate

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01083953

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University Malaya Medical Centre
Kuala Lumpur, Wilayah Persekutuan, Malaysia, 59100
Sponsors and Collaborators
University of Malaya
Malaysian Society of Anaesthesiologists
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Principal Investigator: Cindy Thomas Joseph Department of Anaesthesiology, UMMC
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Responsible Party: Cindy Thomas Joseph, doctor, University of Malaya Identifier: NCT01083953    
Other Study ID Numbers: supreme sevo vs des
First Posted: March 10, 2010    Key Record Dates
Last Update Posted: December 3, 2015
Last Verified: December 2015
Keywords provided by Cindy Thomas Joseph, University of Malaya:
end tidal concentration
Additional relevant MeSH terms:
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Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General
Central Nervous System Depressants
Physiological Effects of Drugs