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The Correlation of Heart Hemodynamic Status Between 320 Multidetector Computed Tomography, Echocardiography and Cardiac Catheterization in Patients With Coronary Artery Disease

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ClinicalTrials.gov Identifier: NCT01083134
Recruitment Status : Unknown
Verified June 2011 by Chang Gung Memorial Hospital.
Recruitment status was:  Recruiting
First Posted : March 9, 2010
Last Update Posted : July 29, 2014
Sponsor:
Information provided by (Responsible Party):
Chang Gung Memorial Hospital

Brief Summary:

With the advances in multidetector computed tomography (MDCT) technology, CT angiography (CTA) of the coronary arteries using 64-slice or dual-source CT systems has evolved into a robust, alternative, noninvasive imaging technique to rule out coronary artery disease (CAD). Reported sensitivities and specificities of coronary CTA can compete with those of catheter angiography.

Because CT is the major source of ionizing radiation in medicine, dual isotope myocardial perfusion scintigraphy and coronary CTA 16-, 64-slice MDCT and DSCT scanners are associated with the highest amount of radiation dose. Recently, a new generation of MDCT machines with even more detector row (320) has become clinically available. The maximum detector width of 16 cm enables the entire heart to be examined in a single rotation and within a single heartbeat and is expected to substantially reduce artifacts from breathing and body motion. Due to high volume coverage, 320-slice CT machines are able to perform a nonspiral, ECG-gated examination of the heart within a single breath-hold.

The purpose of this study was to investigate the correlation of hemodynamic status of 320 MDCT, echocardiography, and coronary catheterization in patients who suspected coronary artery disease.


Condition or disease
Coronary Artery Disease

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Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : March 2010
Estimated Primary Completion Date : March 2015
Estimated Study Completion Date : March 2020

Resource links provided by the National Library of Medicine


Group/Cohort
percentage of stenosis



Primary Outcome Measures :
  1. all cause mortality [ Time Frame: one year ]


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
According to Diamond and Forrester colleague, there are risks including age, gender, smoking, diabetes, and dyslipidemia for coronary artery disease.
Criteria

Inclusion Criteria:

  1. Intermediate or high risk for coronary artery disease
  2. Healthy volunteers

Exclusion Criteria:

  1. Unstable angina
  2. Acute myocardial infarction
  3. Active cancer status
  4. Renal failure(Creatinine > 1.5 mg/dl)
  5. Contrast allergy history
  6. Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01083134


Locations
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Taiwan
Cheng Gung Memorial Hospital at Linkou Recruiting
Taipei, Taiwan
Contact: Tsang-Tang Hsieh, MD    +886 -3-3196200 ext 3656    tth3388@adm.cgmh.org.tw   
Principal Investigator: Cheng Hung Lee, MD         
Sponsors and Collaborators
Chang Gung Memorial Hospital
Publications:

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Responsible Party: Chang Gung Memorial Hospital
ClinicalTrials.gov Identifier: NCT01083134    
Other Study ID Numbers: 98-4077B
First Posted: March 9, 2010    Key Record Dates
Last Update Posted: July 29, 2014
Last Verified: June 2011
Keywords provided by Chang Gung Memorial Hospital:
CAD
Additional relevant MeSH terms:
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Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases