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Clinical Pharmacists Role in the Management of Hypertension in Jordan

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01079494
Recruitment Status : Completed
First Posted : March 3, 2010
Last Update Posted : April 7, 2010
Jordan Hospital
Information provided by:
University of Jordan

Brief Summary:
Background: studies have demonstrated the crucial role of clinical pharmacists as integrated part of heath care team. Not only in Jordan but also in the Middle East region, clinical pharmacy practice is not well established. This current study is the first to evaluate physicians - pharmacists' collaborative approach to uncontrolled blood pressure in Jordan and the Middle East.

Condition or disease Intervention/treatment Phase
Hypertension Other: pharmaceutical care services Not Applicable

Detailed Description:

Objective: this study aimed to evaluate clinical pharmacists' role in the management of uncontrolled hypertensive patients in Jordan. Design: single blinded randomized controlled clinical trial. Patients: 253 patients with uncontrolled hypertension specified as higher blood pressure readings than the recommended goals by the seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure (JNC VII) at the time of enrollment.

Interventions: patients were randomly allocated to an intervention or control group: 130 and 123 patients, respectively. Patients in both arms were followed up for 6 months. In the intervention group, patients were managed by physician-clinical pharmacist team. In the control group, patients were managed by physician(s) only and were not provided pharmaceutical care services.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 266 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Health Services Research
Official Title: Clinical Pharmacists Role in the Management of Hypertension in Jordan
Study Start Date : March 2009
Actual Primary Completion Date : November 2009
Actual Study Completion Date : November 2009

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Active Comparator: intervention group
physician-pharmacist teamwork
Other: pharmaceutical care services
Patients treatment related problems and therapeutic needs or complains identified by clinical pharmacist and managed collaboratively by both pharmacist and the physician.

No Intervention: control
physician only team

Primary Outcome Measures :
  1. percentage of patients who achieved blood pressure goals specified by the JNC VII at each group [ Time Frame: 6 month ]
    defined a goal to be achieved if the systolic blood pressure fell below 140 mm Hg and the diastolic blood pressure fell below 90 mm Hg. Or systolic blood pressure fell below 130 mm Hg and the diastolic blood pressure fell below 80 mm Hg if patient was diabetic.

Secondary Outcome Measures :
  1. mean reductions in both systolic and diastolic blood pressure readings [ Time Frame: 6 months ]
    mean reductions in systolic blood pressure (Systolic blood pressure at enrollment - Systolic blood pressure last follow up visit) and diastolic BP (Diastolic blood pressure at enrollment - Diastolic blood pressure last follow up visit) for both study groups

Information from the National Library of Medicine

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Ages Eligible for Study:   21 Years to 88 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with uncontrolled BP, receiving 0-3 antihypertensive drugs with no change in the regimen or dose within the past 3 month.

Exclusion Criteria:

  • Patients with hypertensive urgency or emergency with BP more than (180/110).
  • Patients with recent stroke or myocardial infraction (within past 6 months).
  • Patients with Class III or IV Chronic heart Failure (CHF).
  • Patients with Unstable angina.
  • Patients with Serious renal or hepatic disease.
  • Pregnant patients.
  • Patients with Dementia or cognitive impairment.
  • If the patient is unable to provide informed written consent.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01079494

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family medicine clinic JUH
Amman, Jordan, 13046
Sponsors and Collaborators
University of Jordan
Jordan Hospital
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Principal Investigator: Eman Hammad, MSc University of Jordan/ Faculty of Pharmacy
Study Director: Abla Al bsoul, PhD University of Jordan/ Faculty of Pharmacy
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Responsible Party: Eman Hammad, faculty of pharmacy / University of Jordan Identifier: NCT01079494    
Other Study ID Numbers: JU8071383
First Posted: March 3, 2010    Key Record Dates
Last Update Posted: April 7, 2010
Last Verified: March 2009
Keywords provided by University of Jordan:
Uncontrolled blood pressure
Additional relevant MeSH terms:
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Vascular Diseases
Cardiovascular Diseases