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Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01078831
Recruitment Status : Completed
First Posted : March 2, 2010
Last Update Posted : November 11, 2010
Information provided by:
Oslo University Hospital

Brief Summary:
The purpose of this study is to examine changes in ventilation and airway pressures during conventional bronchoscopy of intubated patients.

Condition or disease Intervention/treatment
Acute Respiratory Distress Syndrome Acute Lung Injury (ALI) Other: Bronchoscopy

Detailed Description:
Mechanically ventilated patients often need bronchoscopy as a diagnostic procedure or for visually directed elimination of secretions. Partial endotracheal tube occlusion by the bronchoscope increases airflow resistance. Inhibition of inspiratory flow may be compensated for by augmented inspiratory pressure. Reduced expiratory flow however, cannot be compensated for by most ventilators and could lead to higher airway - and intrathoracic pressures that are not detected by pressure transducers in the ventilator tubing. In this study we compare changes in ventilation, airway pressures, ventilator pressures and blood gases during bronchoscopy of intubated patients in both volume controlled and pressure controlled ventilation. Our hypothesis are that 1) increased resistance in the tube during bronchoscopy leads to high intrabronchial airway pressures when the ventilator is in volume controlled mode, and 2) when the ventilator is in pressure controlled mode, increased resistance in the tube during bronchoscopy leads to reduced Tidal Volume and moderately increased paCO2.

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Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Intrabronchial Airway Pressures in Intubated Patients During Bronchoscopy Under Volume Controlled (VC) and Pressure Controlled (PC) Ventilation
Study Start Date : March 2002
Actual Primary Completion Date : April 2010
Actual Study Completion Date : April 2010

Group/Cohort Intervention/treatment
ARDS / ALI patients Other: Bronchoscopy
Airway pressures, ventilation changes and blood gas changes are recorded in a group of intubated patients on mechanical ventilation before and after bronchoscope insertion. The registration is done immediately before a therapeutic/diagnostic bronchoscopy requested by a staff physician not involved n the study.

Primary Outcome Measures :
  1. Changes in ventilation, airway pressures and blood gases after bronchoscope insertion. [ Time Frame: 2 minutes after bronchoscope insertion/ mode change ]
    paO2, paCO2 (kPa), airway and ventilator pressures (cmH2O)

Biospecimen Retention:   Samples Without DNA
Arterial blood gases

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
ARDS/ALI patients on mechanical ventilation where a therapeutic or diagnostic bronchoscopy has been requested by the staff physician.

Inclusion Criteria:

  • ARDS/ALI patients on mechanical ventilation
  • endotracheal tube size 7-9mm
  • age > 18 years
  • therapeutic or diagnostic bronchoscopy requested by staff physician

Exclusion Criteria:

  • SpO2 < 90%
  • unstable BP
  • pneumothorax
  • acute cardiovascular disease
  • cerebrovascular or other condition that requires stable BP and saturation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01078831

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Oslo University Hospital - Ulleval
Oslo, Norway, 0407
Sponsors and Collaborators
Oslo University Hospital
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Study Director: Helge Opdahl, MD, PhD Oslo University Hospital - Ulleval, Norway
Study Director: Ole H Skjønsberg, MD, PhD Ullevaal University Hospital
Study Director: Fredrik Borchsenius, MD Ullevaal University Hospital
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Responsible Party: Fredrik Borchsenius, MD, Head of Department for Pulmonary Medicine, Oslo University Hospital Identifier: NCT01078831    
Other Study ID Numbers: REK-HO Ref 191-01055, 03052001
First Posted: March 2, 2010    Key Record Dates
Last Update Posted: November 11, 2010
Last Verified: November 2010
Additional relevant MeSH terms:
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Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Lung Injury
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Thoracic Injuries
Wounds and Injuries