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Cognitive and Mood Effects of Docosahexaenoic Acid (DHA)-Rich and Eicosapentaenoic Acid (EPA)-Rich Fish Oil in Healthy Young Adults

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01075919
Recruitment Status : Completed
First Posted : February 25, 2010
Last Update Posted : February 25, 2010
Ginsana SA
Information provided by:
Northumbria University

Brief Summary:
To date, only a small handful of studies have assessed the effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cognitive function in healthy adults. The results from these studies are mixed, and have differed greatly in terms of methodology as regards sample size, treatment formulation and duration of the intervention. In order to address these issues, the present study aims to assess the effects of two different formulations of fish oil in parallel, and at doses consistent with the current recommended daily intake of oily fish, across a range of cognitive domains. The aim of the present investigation is therefore to specifically evaluate the effects of 12 weeks supplementation of DHA-rich fish oil and EPA-rich fish oil dietary supplements on cognitive function in healthy young adults maintaining a regular diet containing oily fish not more than once a week. Self-report mood assessments will form the secondary part of this investigation.

Condition or disease Intervention/treatment Phase
Cognitive Function Mood Dietary Supplement: n-3 PUFAs Dietary Supplement: Placebo Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 159 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: Cognitive and Mood Effects of DHA-rich and EPA-rich Fish Oil in Healthy Young Adults
Study Start Date : December 2007
Actual Primary Completion Date : December 2008
Actual Study Completion Date : December 2008

Resource links provided by the National Library of Medicine

Drug Information available for: Fish oil

Arm Intervention/treatment
Active Comparator: DHA-rich fish oil
1 g DHA-rich fish oil containing 450 mg DHA + 90 mg EPA
Dietary Supplement: n-3 PUFAs
1 g DHA-rich fish oil taken daily for 12 weeks

Active Comparator: EPA-rich fish oil
1 g EPA-rich fish oil containing 300 mg EPA + 200 mg DHA
Dietary Supplement: n-3 PUFAs
1 g EPA-rich fish oil taken daily for 12 weeks

Placebo Comparator: Placebo
1 g Olive oil
Dietary Supplement: Placebo
1 g olive oil taken daily for 12 weeks

Primary Outcome Measures :
  1. Cognitive performance [ Time Frame: 12 weeks ]
    Performance is assessed using the COMPASS (Computerised Mental Performance Assessment) system, which presents a battery of standard cognitive tasks assessing aspects of attention, memory and executive function. The Cognitive Demand Battery (30 minutes)will also be administered and assesses cognitive performance under mental fatigue.

Secondary Outcome Measures :
  1. Mood [ Time Frame: 12 weeks ]
    Mood will be evaluated using Bond-Lader VAS and the Depression, Anxiety and Stress Scales.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Male/Female
  • 18-35 years
  • Healthy
  • No herbal supplements/prescription medications (excl. contraceptive pill)
  • Non smoker
  • Native English speaker

Exclusion Criteria:

  • Consumes ≥ 1 portion oily fish/week
  • takes omega-3 supplement
  • Food allergies to treatment ingredients

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01075919

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United Kingdom
Northumbria University
Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 8ST
Sponsors and Collaborators
Northumbria University
Ginsana SA
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Principal Investigator: Philippa A Jackson Northumbria University
Additional Information:
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Responsible Party: Philippa Jackson, Northumbria University Identifier: NCT01075919    
Other Study ID Numbers: 16N1
First Posted: February 25, 2010    Key Record Dates
Last Update Posted: February 25, 2010
Last Verified: February 2010
Keywords provided by Northumbria University:
n-3 PUFAs
Cognitive function
Healthy young adults
Fish oil