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Improving Gait in Multiple Sclerosis (MS) - Strength Training or Treadmill Walking?

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ClinicalTrials.gov Identifier: NCT01074827
Recruitment Status : Completed
First Posted : February 24, 2010
Last Update Posted : July 8, 2015
Sponsor:
Collaborators:
Norwegian University of Science and Technology
Helse Midt-Norge
Information provided by (Responsible Party):
St. Olavs Hospital

Study Description
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Brief Summary:
The objective of this study is to evaluate the effect of strength training for the lower extremities and treadmill training on walking ability in persons with Multiple Sclerosis. The study is a randomized control trial with two groups and the intervention is 8 weeks of intensive strength training or treadmill walking. Primary outcome measure is walking ability, secondary outcome measures are balance, work economy and strength.

Condition or disease Intervention/treatment Phase
Multiple Sclerosis Other: Strength training and treadmill training Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 28 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Strength Training or Treadmill Walking? A Randomized Control Study on the Effect on Gait in Multiple Sclerosis
Study Start Date : March 2010
Actual Primary Completion Date : April 2011
Actual Study Completion Date : April 2011

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Arms and Interventions
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Arm Intervention/treatment
Experimental: Treadmill group
Specific gait training on treadmill
 Other: Strength training and treadmill training
Eight weeks of intensive strength training or treadmill training
Experimental: Strength training group
Eight weeks of intensive strength training
 Other: Strength training and treadmill training
Eight weeks of intensive strength training or treadmill training


Outcome Measures
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Primary Outcome Measures :
  1. Walking ability [ Time Frame: 8 weeks ]

Secondary Outcome Measures :
  1. Strength [ Time Frame: 8 weeks ]
  2. Work economy O2 [ Time Frame: 8 weeks ]
  3. Balance [ Time Frame: 8 weeks ]

Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Diagnosed with Multiple Sclerosis,classified as relapsing remitting,or primary/secondary progressive
  • Expanded Disability Status Scale (EDSS)score of ≤ 6
  • Reduced walking ability (subjectively experienced)

Exclusion Criteria:

  • persons with a level of ataxia, clinically assessed, that would affect their ability to perform the training.
  • spasticity requiring stretching og treatment with baclofen.
  • Other, not MS-related, conditions affecting walking ability.
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01074827


Locations
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Norway
St. Olavs Hospital
Trondheim, Norway, 7006
Sponsors and Collaborators
St. Olavs Hospital
Norwegian University of Science and Technology
Helse Midt-Norge
Investigators
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Study Chair: Siri M, Brændvik St. Olavs Hospital
More Information
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Publications of Results:

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Responsible Party: St. Olavs Hospital
ClinicalTrials.gov Identifier: NCT01074827    
Other Study ID Numbers: 09/225
First Posted: February 24, 2010    Key Record Dates
Last Update Posted: July 8, 2015
Last Verified: July 2015
Keywords provided by St. Olavs Hospital:
Multiple Sclerosis
Walking ability
Strength
Balance
Treadmill walking
Additional relevant MeSH terms:
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Multiple Sclerosis
Sclerosis
Pathologic Processes
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
 Nervous System Diseases
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases