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The Effects of Joint Effusion on Proprioception

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01060215
Recruitment Status : Completed
First Posted : February 2, 2010
Last Update Posted : February 2, 2010
Information provided by:
The Catholic University of Korea

Brief Summary:
The purpose of this study is to assess the effects of joint effusion on proprioceptive status in patients with knee osteoarthritis (OA).

Condition or disease Intervention/treatment Phase
Osteoarthritis Procedure: Normal saline Not Applicable

Detailed Description:

Proprioception is a sensory modality that provides feedback on the internal status of the body and enables us to perceive joint position and motion.

Osteoarthritis (OA), also called degenerative joint disease, is a major musculoskeletal condition characterized by loss of articular cartilage that leads to pain and loss of function. The most commonly affected joint is the knee, and OA may result in changes that affect not only intracapsular tissues, but also periarticular tissues, such as ligaments, capsules, tendons, and muscles. Many studies have examined the proprioceptive status of knee OA, and subjects with knee OA are known to have impaired proprioception compared with age-matched controls.

Joint effusion is a common symptom associated with chronic degenerative joint condition, but the effects of effusion on knee joint proprioception have not been investigated in detail.

A volume of 20 mL of normal saline was injected into the knee joint cavity of subjects in the experimental group under ultrasonographic guidance. Proprioceptive acuity was assessed by active repositioning of the lower limb using an electrogoniometer to measure knee joint position sense (JPS) under both non-weight-bearing and weight-bearing conditions twice, with a 20-min rest interval.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Official Title: Clinical Trial for the Effects of Joint Effusion on Proprioception
Study Start Date : May 2009
Actual Primary Completion Date : January 2010
Actual Study Completion Date : January 2010

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Active Comparator: Infusion
20cc saline infusion into the knee joint
Procedure: Normal saline
20 cc normal saline injection into the knee joint

No Intervention: No infusion Procedure: Normal saline
20 cc normal saline injection into the knee joint

Primary Outcome Measures :
  1. Proprioceptive acuity in Knee Joint. Proprioceptive acuity (difference between the knee angles at the target and reproduced positions) was assessed by active repositioning of the lower limb after injection or no injection. [ Time Frame: within one hour after intervention ]

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

Or at least two of criteria 2-6 established by the American College of Rheumatology (ACR):

  1. Kellgren and Lawrence (K/L) grade ≥II
  2. morning stiffness <30 min in duration
  3. crepitus on movement of the knee joint
  4. bony tenderness at the knee joint margins
  5. palpable or visible bony enlargement
  6. no palpable warmth.

Exclusion Criteria:

  1. the presence of knee joint effusion determined by ultrasonography
  2. a history of knee injury or surgery
  3. a history of knee injection within 3 months
  4. a history of inflammatory arthritis
  5. taking anticoagulants
  6. balance or gait disturbance
  7. diabetes mellitus.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01060215

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Korea, Republic of
Seoul St. Mary's Hospital
Seoul, Korea, Republic of, 137-701
Sponsors and Collaborators
The Catholic University of Korea
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Study Chair: Jongin Lee, M.D Department of Rehabilitation Medicine, Seoul St. Mary's Hospital

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: JongIn Lee/Department of Rehabilitation Medicine,, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea Identifier: NCT01060215    
Other Study ID Numbers: 52008B000100044
First Posted: February 2, 2010    Key Record Dates
Last Update Posted: February 2, 2010
Last Verified: January 2010
Keywords provided by The Catholic University of Korea:
Additional relevant MeSH terms:
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Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases