COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Effects of Parathyroidectomy on Cardiovascular Risk Factors in Primary Hyperparathyroidism

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01057732
Recruitment Status : Completed
First Posted : January 27, 2010
Last Update Posted : January 27, 2010
Information provided by:
HaEmek Medical Center, Israel

Brief Summary:

Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity. The benefit of surgical treatment in this respect is unclear.

This study was performed to evaluate the impact of parathyroidectomy (PTX) on cardiovascular risk profile.

Condition or disease
Primary Hyperparathyroidism

Detailed Description:

Patients with primary hyperparathyroidism (PHPT) have been shown to have an increased morbidity and mortality mainly due to cardiovascular disease. The precise mechanism of cardiovascular disease in PHPT is not well understood and probably multifactorial. Functional or structural alterations of vascular endothelial and smooth muscle cells may impair the vascular reactivity and lead to accelerated atherogenesis. Several cardiovascular risk factors such as obesity, hypertension, insulin resistance and hyperlipidemia are more prevalent in PHPT compared with controls.Patients with severe form of PHPT had a greater probability of metabolic syndrome (MS) and insulin resistance than patients with mild PHPT and eucalcemic subjects. Although the excess in cardiovascular mortality is significantly and independently related to serum calcium, the connection between the biochemical disturbances and the cardiovascular disorders in PHPT patients is not necessarily a cause-and-effect relationship. Indeed, the impact of surgical cure of hyperparathyroidism on cardiovascular risk factors and mortality is controversial. Some studies suggest that hypertension, dyslipidemia, and derangement of glucose metabolism improve after removal of overactive parathyroid tissue. Others have shown that cardiovascular risk markers remained unaltered after parathyroidectomy (PTX).

The aim of this study was to evaluate whether successful PTX is associated with decreased cardiovascular risk. We investigated indices of metabolic syndrome and insulin resistance as well as various cardiovascular risk factors in patients with manifest PHPT before and one year after successful PTX.

Layout table for study information
Study Type : Observational
Actual Enrollment : 76 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Effect of Parathyroidectomy on Cardiovascular Risk Factors in Patients With Primary Hyperparathyroidism
Study Start Date : January 2005
Actual Primary Completion Date : June 2006
Actual Study Completion Date : December 2006

primary hyperparathyroidism
patients with primary hyperparathyroidism
subjects without primary hyperparathyroidism

Biospecimen Retention:   Samples Without DNA
serum, urine

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients with Primary hyperparathyroidism referred to Endocrine clinic. Controls recruited in community-based health centers.

Inclusion Criteria:

  • Patients with primary hyperparthyroidism

Exclusion Criteria:

  • Individuals with known diabetes mellitus,coronary heart disease, stroke

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01057732

Layout table for location information
Endocrine Institute, Haemek Medical Center
Afula, Israel, 18101
Sponsors and Collaborators
HaEmek Medical Center, Israel
Layout table for additonal information
Responsible Party: Avraham Ishay, Haemek Medical Center, Afula, Israel Identifier: NCT01057732    
Other Study ID Numbers: 3630405
First Posted: January 27, 2010    Key Record Dates
Last Update Posted: January 27, 2010
Last Verified: January 2010
Additional relevant MeSH terms:
Layout table for MeSH terms
Hyperparathyroidism, Primary
Parathyroid Diseases
Endocrine System Diseases