Studying Gene Expression in Tissue Samples From Young Patients With Acute Myeloid Leukemia
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|ClinicalTrials.gov Identifier: NCT01057303|
Recruitment Status : Completed
First Posted : January 27, 2010
Last Update Posted : May 6, 2015
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at gene expression in tissue samples from young patients with acute myeloid leukemia.
|Condition or disease||Intervention/treatment|
|Leukemia||Genetic: RNA analysis Genetic: gene expression analysis Genetic: reverse transcriptase-polymerase chain reaction Other: laboratory biomarker analysis|
- Examine mRNA from pediatric patients with acute myeloid leukemia with 11q23 translocations by reverse transcriptase-PCR to quantify expression of EVI1 splice variants.
OUTLINE: Cryopreserved mRNA from diagnostic samples is analyzed for gene expression by reverse transcriptase-PCR.
|Study Type :||Observational|
|Actual Enrollment :||20 participants|
|Official Title:||EVI-1 Expression in Pediatric AML With 11q23 Abnormalities|
|Study Start Date :||February 2010|
|Actual Primary Completion Date :||June 2010|
|Actual Study Completion Date :||June 2010|
- Quantification of the expression of EVI1 splice variants
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01057303
|Principal Investigator:||Amy Heerema-McKenney, MD||Stanford University|