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Copeptin in Differentiation of Polyuria and Polydipsia

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ClinicalTrials.gov Identifier: NCT01056887
Recruitment Status : Completed
First Posted : January 26, 2010
Last Update Posted : April 25, 2011
Sponsor:
Collaborator:
Dr. Carson Liu Med Corp.
Information provided by:
University of Wuerzburg

Study Description
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Brief Summary:

The differential diagnosis of patients with polyuria/ polydipsia is often complex, but important for the therapeutic strategy.

Challenging is in particular the clinical differentiation between patients with a partial Diabetes insipidus centralis and patients with primary polydipsia as underlying disease, because both groups are associated with similar urinary osmolalities.

The determination of plasma arginine vasopressin is unusual in this context, since measurement of AVP is not reliably.

C-terminal ProVasopressin (copeptin) is secreted stoichiometrically with AVP from the neurohypophysis, but has a longer half life in the circulation, and is thus easier to measure.

Therefore, the investigators will analyze in that study the diagnostic utility of plasma copeptin in the differential diagnosis of polyuria and polydipsia.


Condition or disease
Polyuria Polydipsia

Study Design
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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : March 2008
Actual Primary Completion Date : November 2010
Actual Study Completion Date : November 2010

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Groups and Cohorts
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Group/Cohort
Primary Polydip, D. insipidus


Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Healthy probands Patients with diabetes insipdus centralis totalis/ partials Patients with diabetes insipidus renalis Patients with primary polydipsia
Criteria

Inclusion Criteria:

  • Patients with polydipsia/ polyuria, with indication for performing a deprivation test
  • > 18 years

Exclusion Criteria:

  • dDAVP during the last 14d
  • pregnancy
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01056887


Locations
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Germany
Univ Hospital Wuerzburg
Wuerzburg, Bavaria, Germany, 97080
Sponsors and Collaborators
University of Wuerzburg
Dr. Carson Liu Med Corp.
More Information
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Top of Page Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Prof. Dr. med. Bruno Allolio, FDAAA
ClinicalTrials.gov Identifier: NCT01056887    
Other Study ID Numbers: 17121979
33/07
First Posted: January 26, 2010    Key Record Dates
Last Update Posted: April 25, 2011
Last Verified: November 2010
Keywords provided by University of Wuerzburg:
diabetes insipidus
primary polydipsia
copeptin
Utility of plasma copeptin in differential diagnosis of polyuria/ polydipsia while performing a traditional deprivation test
Additional relevant MeSH terms:
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Polyuria
Polydipsia
Urination Disorders
 Urologic Diseases
Urological Manifestations
Pathologic Processes