Stapler Hepatectomy for Elective Liver Resection (CRUNSH)
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ClinicalTrials.gov Identifier: NCT01049607 |
Recruitment Status :
Completed
First Posted : January 14, 2010
Last Update Posted : May 17, 2013
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Hepatic Resection | Procedure: Clamp-Crush technique Procedure: Stapler hepatectomy | Phase 3 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 130 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | Clamp-Crushing vs. Stapler Hepatectomy for Transection of the Parenchyma in Elective Hepatic Resection: CRUNSH - A Randomized Controlled Trial |
Study Start Date : | January 2010 |
Actual Primary Completion Date : | October 2011 |
Actual Study Completion Date : | March 2012 |
Arm | Intervention/treatment |
---|---|
Active Comparator: Clamp-Crush technique |
Procedure: Clamp-Crush technique
The transectional line is marked and the liver capsule is cauterized. The liver parenchyma is then crushed stepwise using a regular Pèan clamp. Vessels and bile ducts are ligated or clipped. Vessels of less than 2mm diameter are coagulated with the irrigated bipolar forceps. |
Experimental: Stapler hepatectomy |
Procedure: Stapler hepatectomy
The transectional line is marked and the liver capsule is cauterized. For subsequent transection of the hepatic parenchyma, the liver tissue is fractured with a vascular clamp in a stepwise fashion and subsequently divided with endo GIA vascular staplers. |
- Intraoperative blood loss [ Time Frame: 2.5 hours ]

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients scheduled for elective hepatic resection
- Stapler hepatectomy and clamp-crushing feasible based on preoperative imaging
- Age equal or greater than 18 years
- Informed consent
Exclusion Criteria:
- Participation in concurrent intervention trials
- Expected lack of compliance
- Impaired mental state or language problems

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01049607
Germany | |
Department of General, Visceral and Transplantation Surgery, University of Heidelberg | |
Heidelberg, BW, Germany, 69120 |
Principal Investigator: | Jürgen Weitz, MD, MSc | Department of General, Visceral and Transplantation Surgery, University of Heidelberg |
Responsible Party: | Nuh Rahbari, M.D. Resident, Heidelberg University |
ClinicalTrials.gov Identifier: | NCT01049607 |
Other Study ID Numbers: |
NNR-03 |
First Posted: | January 14, 2010 Key Record Dates |
Last Update Posted: | May 17, 2013 |
Last Verified: | May 2013 |
Patients undergoing hepatic resection |