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Isovolumetric and Isocaloric Preloads of Various Types of Milk on Food Intake, Subjective Appetite and Glycemic Response

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ClinicalTrials.gov Identifier: NCT01025557
Recruitment Status : Completed
First Posted : December 3, 2009
Last Update Posted : June 14, 2012
Sponsor:
Collaborators:
Dairy Farmers of Ontario
Mondelēz International, Inc.
Natural Sciences and Engineering Research Council, Canada
Information provided by (Responsible Party):
G. Harvey Anderson, University of Toronto

Study Description
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Brief Summary:
The purpose of this protocol is to study the effects of fluid milk products on satiety, food intake, and glucose metabolism in healthy young men and women. Experiment 1: The specific objective is to investigate isovolumetric amounts of milk (2% M.F.), chocolate milk (1% M.F.), a soy beverage, cow's milk-based infant formula, and water (control) on satiety and food intake and on blood glucose before and after a meal. A fixed volume approach is based on the commercially available serving size. Experiment 2 will examine equicaloric amounts of milk (2% M.F.), chocolate milk (1% M.F.), a soy beverage, cow's milk-based infant formula, a glucose drink and water (control) the treatments in order to investigate macronutrient composition on satiety and food intake and on blood glucose before and after the meal.

Condition or disease Intervention/treatment Phase
Diabetes Prevention Obesity Prevention Other: Dietary intervention Phase 1 Phase 2

Study Design
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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 52 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: The Effects of Isovolumetric and Isocaloric Preloads of Various Types of Milk on Food Intake, Subjective Appetite and Glycemic Response in Healthy Young Men and Women
Study Start Date : September 2009
Actual Primary Completion Date : June 2011
Actual Study Completion Date : May 2012
Arms and Interventions
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Arm Intervention/treatment
Experimental: Chocolate milk Other: Dietary intervention
Dietary treatments with beverages
Experimental: Milk Other: Dietary intervention
Dietary treatments with beverages
Experimental: Infant formula Other: Dietary intervention
Dietary treatments with beverages
Experimental: Soy beverage Other: Dietary intervention
Dietary treatments with beverages
Experimental: Water Other: Dietary intervention
Dietary treatments with beverages


Outcome Measures
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Primary Outcome Measures :
  1. Food intake [ Time Frame: 30 minute ]

Secondary Outcome Measures :
  1. Blood glucose [ Time Frame: 0, 10, 20, 30, 50, 80, 110, 140 and 170 minutes ]

Eligibility Criteria
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Ages Eligible for Study:   20 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy
  • Non-smoking
  • Aged 20-30 years
  • Body mass index between 20 and 24.9 kg/m2

Exclusion Criteria:

  • Diabetes
  • Medication
  • Lactose-intolerance or allergies to milk
  • Breakfast skippers and those on an energy restricted diet
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01025557


Locations
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Canada, Ontario
University of Toronto
Toronto, Ontario, Canada, M5S 3E2
Sponsors and Collaborators
University of Toronto
Dairy Farmers of Ontario
Mondelēz International, Inc.
Natural Sciences and Engineering Research Council, Canada
Investigators
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Principal Investigator: Harvey Anderson, Ph.D. University of Toronto
More Information
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Responsible Party: G. Harvey Anderson, Professor, University of Toronto
ClinicalTrials.gov Identifier: NCT01025557    
Other Study ID Numbers: Milk Study - Experiment 1
DFO_24235
First Posted: December 3, 2009    Key Record Dates
Last Update Posted: June 14, 2012
Last Verified: June 2012
Keywords provided by G. Harvey Anderson, University of Toronto:
Food intake
Blood glucose
Milk