Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans (VINE)

• ClinicalTrials.gov Identifier: NCT01024634
• Recruitment Status: Completed
• First Posted: December 3, 2009
• Last Update Posted: December 17, 2012
• Sponsor: University of Illinois at Urbana-Champaign
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Information provided by (Responsible Party): Bo Fernhall, University of Illinois at Urbana-Champaign

Study Description

Brief Summary:

The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of age) African Americans when compared to Caucasians.

Condition or disease	Intervention/treatment	Phase
Vascular Health; Autonomic Function	Behavioral: Endurance Exercise	Not Applicable

Detailed Description:

African-Americans are at greater risk than Caucasians for developing hypertension, cardiovascular disease, stroke and renal disease. This is likely related to arterial dysfunction including greater arterial stiffness, and reduced microvascular reactivity of resistance arteries in African-Americans. In addition, African-Americans have higher levels of inflammatory markers, and a greater sympathoexcitatory response to various stressors. This imbalance between sympathetic and reduced parasympathetic activation may directly affect vascular function and potentiate a greater inflammatory response, further altering key structural and functional properties of the vascular wall. The overall aim of this proposal is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of age) African Americans when compared to Caucasians. We will examine these effects at rest and following a high intensity (maximal cycle ergometry) sympathoexcitation at both pre- and post-intervention time points, since sympathoexcitation may elucidate changes not evident at rest. Because African-Americans have higher levels of arterial stiffness, lower microvascular reactivity, greater responses to sympathoexcitation, greater levels of inflammatory markers and greater vasoconstrictive tone, we hypothesize that African-Americans will show differential responses to exercise training and benefit more compared to a matched group of Caucasians.

Study Design

• Study Type: Interventional (Clinical Trial)
• Actual Enrollment: 91 participants
• Allocation: Non-Randomized
• Intervention Model: Crossover Assignment
• Masking: None (Open Label)
• Primary Purpose: Prevention
• Official Title: Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans
• Study Start Date: September 2009
• Actual Primary Completion Date: July 2011
• Actual Study Completion Date: December 2012

Arms and Interventions

Arm	Intervention/treatment
African American Group; A group of young African American males and females	Behavioral: Endurance Exercise; 8 weeks of Endurance exercise training, 3-4 times per week, 45-60 minutes perr session
Caucasian Group; a group of young Caucasian men and women	Behavioral: Endurance Exercise; 8 weeks of Endurance exercise training, 3-4 times per week, 45-60 minutes perr session

Outcome Measures

Primary Outcome Measures :

1. Arterial function [ Time Frame: Pre, following a 4 week control period and after 8 weeks of exercise intervention ]

Secondary Outcome Measures :

1. Autonomic function [ Time Frame: Pre, following a 4 week control period and following 8 weeeks of an exercise intervention ]

Eligibility Criteria

• Ages Eligible for Study: 18 Years to 35 Years (Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Criteria

Inclusion Criteria:

• Subjects in good health with no cardiovascular, metabolic, or inflammatory disease, who do not use cardiovascular medications or antioxidant vitamin supplementation, including use of anti-inflammatory (including aspirin) or steroidal substances in the past 2 months will be inlcuded

Exclusion Criteria:

• Subjects who smoke, are severely obese (body mass index > 35 kg/m2), or who have hypertension (blood pressure >140/90mmHg), diabetes (fasting glucose >110mg/dl), hyperlipidemia, inflammatory disease (rheumatoid arthritis and systemic lupus erythematosus, etc) or diagnosed cardiovascular disease including, coronary heart disease, hypertension and cardiac arrhythmia or renal disease, will be excluded

Contacts and Locations

Locations

United States, Illinois

Kinesiology and Community Health Department, University of Illinois at Urbana-Champaign

Urbana, Illinois, United States, 61801

Sponsors and Collaborators

University of Illinois at Urbana-Champaign

National Heart, Lung, and Blood Institute (NHLBI)

Investigators

• Principal Investigator: Bo Fernhall, Ph.D.; University of Illinois at Urbana-Champaign

More Information

• Responsible Party: Bo Fernhall, Professor, University of Illinois at Urbana-Champaign
• ClinicalTrials.gov Identifier: NCT01024634
• Other Study ID Numbers: UIUC 09599; 1R01HL093249-01A1 ( U.S. NIH Grant/Contract )
• First Posted: December 3, 2009
• Last Update Posted: December 17, 2012
• Last Verified: December 2012

Keywords provided by Bo Fernhall, University of Illinois at Urbana-Champaign:

Arterial stiffness; Endothelial function; Autonomic function; Inflammation