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Epidemiology and Clinical Presentation of H1N1 Infection in Children in Geneva

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ClinicalTrials.gov Identifier: NCT01022931
Recruitment Status : Completed
First Posted : December 1, 2009
Last Update Posted : December 11, 2012
Sponsor:
Information provided by (Responsible Party):
Klara M. Pósfay Barbe, University Hospital, Geneva

Brief Summary:
This study aims to identify clinical symptoms and outcomes, as well as response to anti-viral treatment in children living in Geneva, with influenza A/ H1N1 infection during the current pandemic.

Condition or disease
Healthy Immunosuppressed Asthmatic Neuromuscular Diseases

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Study Type : Observational
Actual Enrollment : 200 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Evaluation of a New Virus(Influenza A H1N1/09) in Children: Epidemiology, Clinical Presentation and Outcome, and Response to Treatment
Study Start Date : October 2009
Actual Primary Completion Date : February 2010
Actual Study Completion Date : July 2012



Primary Outcome Measures :
  1. ABCB1 polymorphisms [ Time Frame: 6 months ]
    ABCB1 gene polymorphisms and neuropsychiatric adverse events in oseltamivir-treated children during influenza H1N1/09 pandemia


Biospecimen Retention:   Samples With DNA
Nasal swab; DNA for genetic polymorphisms (Response to oseltamivir)


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Ages Eligible for Study:   up to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Children seen at the emergency ward
Criteria

Inclusion Criteria:

  • suspicion of H1N1 infection

Exclusion Criteria:

  • Not available for a 30 days follow-up

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01022931


Locations
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Switzerland
Children's Hospital of Geneva, HUG
Geneva, GE, Switzerland, 1211
Sponsors and Collaborators
University Hospital, Geneva
Investigators
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Principal Investigator: Klara M Posfay-Barbe, MD, MS University Hospitals of Geneva

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Responsible Party: Klara M. Pósfay Barbe, Head of Pediatric Infectious Diseases, University Hospital, Geneva
ClinicalTrials.gov Identifier: NCT01022931     History of Changes
Other Study ID Numbers: H1N1epidemiology
First Posted: December 1, 2009    Key Record Dates
Last Update Posted: December 11, 2012
Last Verified: December 2012

Keywords provided by Klara M. Pósfay Barbe, University Hospital, Geneva:
Influenza A H1N1
Children
Epidemiology
Treatment
Oseltamivir
Genetics

Additional relevant MeSH terms:
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Neuromuscular Diseases
Nervous System Diseases