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Retinal Function in Parkinson's Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01010074
Recruitment Status : Unknown
Verified November 2009 by Edward Hines Jr. VA Hospital.
Recruitment status was:  Recruiting
First Posted : November 9, 2009
Last Update Posted : November 9, 2009
Information provided by:
Edward Hines Jr. VA Hospital

Brief Summary:
Parkinson's disease (PD) is a neurodegenerative disorder characterized by muscle rigidity, tremor, a slowing of physical movement (bradykinesia) and, in extreme cases, a loss of physical movement. The primary symptoms are the results of decreased stimulation of the motor cortex arising from the basal ganglia normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Secondary symptoms may include high level cognitive dysfunction and subtle language problems. Included in the symptomatology experienced by patients with PD, visual abnormalities are not uncommon. Visual changes among patients with PD appear not only dynamic in nature, but differentially affected based on the course of the disease and, perhaps more importantly, its treatment. Parkinson's disease has significant ramifications not only in observation of irregularities in vision, but how vision interacts with entrainment of the circadian clock. The purpose of this study is to examine the relationship between PD and operation of a unique set of retinal cells known to regulate the circadian clock and sleep-wake cycles in human subjects.

Condition or disease
Parkinson's Disease

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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Intrinsically Photosensitive Retinal Ganglion Cells in Parkinson's Disease
Study Start Date : October 2009
Estimated Primary Completion Date : December 2010
Estimated Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. pupillary threshold [ Time Frame: one ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
movement disorders/neurology clinic

Inclusion Criteria: age 18-64 best corrected visual acuity of 20/25 or better in each eye -

Exclusion Criteria: evidence of any form of eye disease, inability to understand and sign informed consent.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01010074

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Contact: Bruce Ira Gaynes, OD, PharmD 708-216-6262
Contact: Jasvinder Chawla, MD 708-202-3800

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United States, Illinois
Hines VA Medical Center Recruiting
Hines, Illinois, United States, 60141
Contact: Bruce Ira Gaynes, OD, PharmD    708-216-6262   
Sponsors and Collaborators
US Department of Veterans Affairs
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Responsible Party: Bruce I. Gaynes, OD, PharmD, Hines VA Medical Center Identifier: NCT01010074    
Other Study ID Numbers: PD001
First Posted: November 9, 2009    Key Record Dates
Last Update Posted: November 9, 2009
Last Verified: November 2009
Keywords provided by Edward Hines Jr. VA Hospital:
retina, Parkinson's disease, ganglion cell, pupillary
Additional relevant MeSH terms:
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Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases