Measured Hypocretin Levels and Recovery After Hip Surgery
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01009710
Recruitment Status : Unknown
Verified January 2017 by Anthony Doufas, Stanford University. Recruitment status was: Active, not recruiting
A specific group of neurons in the brain produces hypocretin, a peptide which has been established as an important regulator of sleep and wakefulness. Activation of these neurons (increased hypocretin) stabilizes wakefulness; impairing or blocking these neurons (decreased hypocretin) promotes sleep. Evidence suggests that these neurons may be involved in the hypnotic properties of several anesthetics, and play a role in the induction and emergence from anesthesia. In humans there is a considerable inter-individual variability in hypocretin levels. This study aims to investigate how hypocretin levels affect the anesthetic care and recovery of patients undergoing elective hip surgery.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients scheduled for elective total hip arthroplasty through the Stanford Orthopedic Clinic.
Inclusion Criteria:- Adult (18 years of age or older)
Male or female
Scheduled for elective total hip arthroplasty at the Stanford Orthopedic Clinic.
Comprehend spoken and written English Exclusion Criteria:- ASA physical status > III (patients with severe systemic disease)