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MSG and Gastrointestinal Motility

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01009658
Recruitment Status : Completed
First Posted : November 9, 2009
Last Update Posted : March 26, 2015
Information provided by (Responsible Party):
Hiroko Hosaka, Gunma University

Brief Summary:
The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).

Condition or disease Intervention/treatment Phase
Gastroesophageal Reflux Dietary Supplement: Monosodium glutamate Dietary Supplement: Sodium chloride Not Applicable

Detailed Description:

Amino acids such as monosodium glutamate are known to stimulate both endocrine and exocrine secretion. In addition, there is a report that oral intake of glutamate evokes the activation of vagal afferent nerves in the rat. Thus, such amino acids are thought to be influential in the process of digestion and absorption.

. To investigate the effect of monosodium glutamate on gastrointestinal motility, we planned a single-blind randomized study. The participants will take either monosodium glutamate or sodium chloride before the first examination of upper GI motility and the other agent before the second examination. The order of intake will be randomized by the envelope method.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Effect of Monosodium Glutamate on Upper Gastrointestinal Tract Motility
Study Start Date : December 2009
Actual Primary Completion Date : March 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: GERD

Arm Intervention/treatment
Active Comparator: MSG first Dietary Supplement: Monosodium glutamate
Oral intake of 2.0 g of monosodium glutamate on the examination day and 0.6 g of sodium chloride on the other examination day.

Placebo Comparator: NaCl first Dietary Supplement: Sodium chloride
Oral intake of 0.6 g of sodium chloride on the examination day and 2.0 g of monosodium glutamate on the other examination day.

Primary Outcome Measures :
  1. Gastric emptying [ Time Frame: 0-5 hours ]
    half emptying time

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy subjects
  • Must not have digestive symptoms
  • Must not eat within six hours of study participation

Exclusion Criteria:

  • Regular medications for the gastrointestinal tract
  • Previous Helicobacter pylori infection
  • Previous abdominal surgery

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01009658

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Gunma university hospital
Maebashi, Gunma, Japan, 3718511
Sponsors and Collaborators
Gunma University
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Responsible Party: Hiroko Hosaka, MD, Gunma University Identifier: NCT01009658    
Other Study ID Numbers: GU-696
GU-CT 696
First Posted: November 9, 2009    Key Record Dates
Last Update Posted: March 26, 2015
Last Verified: March 2015
Keywords provided by Hiroko Hosaka, Gunma University:
Gastrointestinal motility
Gastroesophageal reflux
Gastric emptying
Sodium glutamate
Lower esophageal sphincter
Additional relevant MeSH terms:
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Gastroesophageal Reflux
Esophageal Motility Disorders
Deglutition Disorders
Esophageal Diseases
Gastrointestinal Diseases
Digestive System Diseases