MSG and Gastrointestinal Motility
|ClinicalTrials.gov Identifier: NCT01009658|
Recruitment Status : Completed
First Posted : November 9, 2009
Last Update Posted : March 26, 2015
|Condition or disease||Intervention/treatment||Phase|
|Gastroesophageal Reflux||Dietary Supplement: Monosodium glutamate Dietary Supplement: Sodium chloride||Not Applicable|
Amino acids such as monosodium glutamate are known to stimulate both endocrine and exocrine secretion. In addition, there is a report that oral intake of glutamate evokes the activation of vagal afferent nerves in the rat. Thus, such amino acids are thought to be influential in the process of digestion and absorption.
. To investigate the effect of monosodium glutamate on gastrointestinal motility, we planned a single-blind randomized study. The participants will take either monosodium glutamate or sodium chloride before the first examination of upper GI motility and the other agent before the second examination. The order of intake will be randomized by the envelope method.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||40 participants|
|Intervention Model:||Crossover Assignment|
|Primary Purpose:||Basic Science|
|Official Title:||Effect of Monosodium Glutamate on Upper Gastrointestinal Tract Motility|
|Study Start Date :||December 2009|
|Actual Primary Completion Date :||March 2015|
|Active Comparator: MSG first||
Dietary Supplement: Monosodium glutamate
Oral intake of 2.0 g of monosodium glutamate on the examination day and 0.6 g of sodium chloride on the other examination day.
|Placebo Comparator: NaCl first||
Dietary Supplement: Sodium chloride
Oral intake of 0.6 g of sodium chloride on the examination day and 2.0 g of monosodium glutamate on the other examination day.
- Gastric emptying [ Time Frame: 0-5 hours ]half emptying time
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01009658
|Gunma university hospital|
|Maebashi, Gunma, Japan, 3718511|