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Cardiovascular Risk Factors After Renal Transplantation in Children and Adults (HENT)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01008306
Recruitment Status : Unknown
Verified November 2009 by Oslo University Hospital.
Recruitment status was:  Active, not recruiting
First Posted : November 5, 2009
Last Update Posted : November 5, 2009
Norwegian Red Cross
Information provided by:
Oslo University Hospital

Brief Summary:

Renal transplantation of children started in Norway in 1970.Since the beginning, >80% of renal transplants are provided from Living Donors(mainly parents), short pre-transplant dialysis time( median 4 months) and 50% of transplantations are performed before dialysis is needed.This gives good premises for graft survival and avoidance of detrimental effects of dialysis. However, renal transplanted children are subjected to an increased cardiovascular morbidity and mortality in adulthood due to consequences of chronic renal failure and immunosuppressive treatment.Cardiovascular death comprises 30-40% of death causes. In this cross-sectional study we evaluate cardiovascular risk factors in childhood- and also in young adults renal transplanted in childhood.

Focus is cardiorespiratory fitness using treadmill testing,24h BP measurements, anthropometrics including waist circumference,echocardiography,intima media thickness of carotids, glucose intolerance test.Participants are also requested to fill out physical activity recalls and Quality of life questionnaires.

Condition or disease
Exercise Capacity Physical Activity Hypertension Overweight and Obesity Metabolic Syndrome

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Outcome After Pediatric Renal Transplantation: Cardiorespiratory Fitness, Cardiovascular Risk Factors and Quality of Life
Study Start Date : June 2007
Estimated Primary Completion Date : June 2010

Resource links provided by the National Library of Medicine

Renal transplanted children and young adults

Renal transplanted children and adolescents (2-18yrs) transplanted between 1993-2006.

Renal transplanted young adults aged 20-35 yrs old, transplanted from 1983 onwards.

Secondary Outcome Measures :
  1. other cardiovascular risk factors [ Time Frame: 2007-2010 ]
  2. hypertension [ Time Frame: 2007-2010 ]
  3. impaired glucose intolerance [ Time Frame: 2007-2010 ]
  4. left ventricular hypertrophy, [ Time Frame: 2007-2010 ]

Biospecimen Retention:   Samples Without DNA
Freezing of serum and plasma from study participants

Information from the National Library of Medicine

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Ages Eligible for Study:   2 Years to 38 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Renal transplanted children, adolescents and young adults transplanted in the period 1983-2006 in the same center (Oslo University Hospital, Rikshospitalet)

Inclusion Criteria:

  • Transplanted after 1983, functioning graft

Exclusion Criteria:

  • Patients in dialysis
  • In part of the study concerning treadmill testing: Age<8 years, orthopedic limitations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01008306

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Oslo University Hospital Rikshospitalet HF, Division of Pediatrics
Oslo, Norway, 0027
Sponsors and Collaborators
Oslo University Hospital
Norwegian Red Cross
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Oslo University Hospital, Rikshospitalet HF, Rikshospitalet HF, department of pediatrics Identifier: NCT01008306    
Other Study ID Numbers: S-07245b
First Posted: November 5, 2009    Key Record Dates
Last Update Posted: November 5, 2009
Last Verified: November 2009
Keywords provided by Oslo University Hospital:
Cardiorespiratory fitness
physical activity
overweight and obesity
metabolic syndrome
Body composition
Additional relevant MeSH terms:
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Metabolic Syndrome
Vascular Diseases
Cardiovascular Diseases
Body Weight
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases