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Community Clinic Test of Youth Anxiety Treatment (YADS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01005836
Recruitment Status : Completed
First Posted : November 1, 2009
Last Update Posted : March 30, 2017
Information provided by (Responsible Party):
John Weisz, Harvard University

Brief Summary:
Structured, manualized treatments have been developed for numerous mental health problems and disorders among children and adolescents, and a number of these have shown strong beneficial effects in clinical trials. Such findings have led to proposals that the empirically supported treatments be used to improve outcomes of conventional clinic treatment, which some research suggests may not be very effective. But can these lab-tested treatments actually work in service-oriented clinics with referred youth? Available evidence cannot tell us, because the therapists, conditions, and clientele in the laboratory efficacy tests tend to differ so markedly from those of clinical practice. To assess the clinical potential of efficacy-tested treatments, we need effectiveness research that tests these treatments in the crucible of clinical practice. To help begin this process, the proposed research focuses on a specific treatment program for a specific cluster of disorders: Kendall's (1994) cognitive-behavioral "Coping Cat" program for child and adolescent anxiety disorders. The program has shown unusually positive effects across a series of clinical trials in the U.S. and Australia, but it has never been tested in real-world clinical conditions. The proposed study will test the effectiveness of the treatment with clinic-referred youth, treated in community clinics, with the treatment carried out by clinic staff therapists. Some 128 youth, aged 9-14, referred for anxiety and diagnosed with anxiety disorders, will be randomly assigned to receive either the usual treatment in the clinic, or the Kendall program, carried out by clinic staff who have been trained to proficiency. Therapists for the two treatment conditions will also be chosen randomly, from a pool of volunteers. Outcome assessment at immediate post-treatment, 1-year, and 2-year follow-ups, will test effects across many outcomes. It is hypothesized that outcomes for youths treated using the cognitive-behavioral treatment will be superior to those treated using usual care.

Condition or disease Intervention/treatment Phase
Anxiety Depression Behavioral: Cognitive behavioral therapy for youth anxiety Other: Usual clinic care Behavioral: Cognitive behavioral treatment for youth depression Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 105 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Community Clinic Test of Youth Anxiety and Depression Study
Study Start Date : February 1998
Actual Primary Completion Date : May 2005
Actual Study Completion Date : May 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Anxiety

Arm Intervention/treatment
Experimental: Cognitive-behavioral therapy: Anxiety
CBT for child anxiety. Coping Cat.
Behavioral: Cognitive behavioral therapy for youth anxiety
Other Name: Coping Cat

Usual care: Anxiety
Usual clinic care
Other: Usual clinic care
Experimental: Cognitive behavioral therapy: depression
CBT for youth depression. The Primary and Secondary Control Enhancement Training protocol.
Behavioral: Cognitive behavioral treatment for youth depression
Other Name: PASCET

Usual care: Depression
Usual clinic care for depression
Other: Usual clinic care

Information from the National Library of Medicine

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Ages Eligible for Study:   8 Years to 15 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Primary DSM-IV anxiety or depressive disorder

Exclusion Criteria:

  • Pervasive developmental disorder
  • Psychotic disorder
  • Mental retardation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01005836

Sponsors and Collaborators
Harvard University
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Principal Investigator: John R Weisz, PhD Harvard University

Publications of Results:
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: John Weisz, Professor and Primary Investigator, Harvard University Identifier: NCT01005836    
Other Study ID Numbers: R01MH057347 ( U.S. NIH Grant/Contract )
First Posted: November 1, 2009    Key Record Dates
Last Update Posted: March 30, 2017
Last Verified: March 2017
Keywords provided by John Weisz, Harvard University:
Cognitive behavioral therapy
Anxiety treatment
Depression treatment
Child treatment
Usual care
Additional relevant MeSH terms:
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Depressive Disorder
Anxiety Disorders
Behavioral Symptoms
Mood Disorders
Mental Disorders