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Strength Training for Chronic Stroke Patients

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ClinicalTrials.gov Identifier: NCT01003353
Recruitment Status : Completed
First Posted : October 28, 2009
Last Update Posted : June 25, 2012
Sponsor:
Information provided by (Responsible Party):
Norwegian University of Science and Technology

Brief Summary:

The study aims to investigate the effects of strength training on maximal strength, walking ability and neural function in chronic stroke patients. The strength training intervention in this study is different to all previous interventions for stroke patients.

Maximal Strength Training (MST) involves weights of up to 90% of the participants 1 repetition maximum and has a focus on the explosive development of force. This study will use these principles for unilateral leg press and plantarflexion exercises. Only 2 previous studies have investigated high intensity strength training for stroke patients and they used intensities of 80% 1RM. Previous MST interventions have shown large increases in strength, rate of force development and this has transferred to improved walking economy.

The investigators predict that MST will give large increases in strength, improved rate of force development (RFD) and walking economy. The investigators expect that better neural function will account for the improvements. This study could provide evidence for the adoption of a completely different method of strength rehabilitation for stroke survivors.


Condition or disease Intervention/treatment Phase
Stroke Behavioral: Maximal strength training Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 10 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Maximal Strength Training for Chronic Phase Stroke Patients
Study Start Date : November 2009
Actual Primary Completion Date : March 2010
Actual Study Completion Date : March 2010

Intervention Details:
  • Behavioral: Maximal strength training
    Training will be carried out 3 times a week for 8 weeks. Each session will include a warm up, strength training and warm down. The total time will be approximately 1 hour. The training will consist 2 exercises (leg press and plantarflexion). Participants will train each leg individually with 4 sets of 4 repetitions at 90% of the 1 repetition maximum.


Primary Outcome Measures :
  1. Unilateral 1 repetition maximum for leg press and plantarflexion [ Time Frame: November 2009-March 2010 ]

Secondary Outcome Measures :
  1. Rate of force development in unilateral leg press and plantarflexion [ Time Frame: November 2009 - March 2010 ]
  2. Maximal oxygen uptake and walking economy [ Time Frame: November 2009 - March 2010 ]
  3. Timed Up and Go Test [ Time Frame: November 2009 - March 2010 ]
  4. 4 Step Balance Test [ Time Frame: November 2009 - March 2010 ]
  5. V-Wave (using sEMG equipment) of soleus during static plantarflexion [ Time Frame: November 2009 - March 2010 ]
  6. Blood lipid profile [ Time Frame: November 2009 - March 2010 ]
  7. 6 Minute Walk Test [ Time Frame: November 2009 - March 2010 ]
  8. Jump Height of a countermovement jump [ Time Frame: November 2009 - March 2010 ]
  9. SF-36 Quality of life questionnaire, Norwegian version [ Time Frame: November 2009 - March 2010 ]


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Ages Eligible for Study:   18 Years to 67 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Under 67 years old
  • Suffered from a stroke at least 6 months previously
  • Living in the Trondheim area such that travel costs can be covered by 1500 NOK
  • Must be able to walk, although use of aids is permitted

Exclusion Criteria:

  • Participants must not have cognitive, visuospatial or comprehension deficits to magnitude such that it interferes with the ability to perform testing and training
  • Participants must be medically unstable (e.g. uncontrollably high blood pressure (140/90), arrythmia, other heart instabilities or other known comorbid diseases)
  • Participants must not be known to be pregnant

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01003353


Locations
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Norway
Avdeling for ervervede hjerneskader, Klinikk for fysikalsk medisin og rehabilitering, St Olavs Hospital
Trondheim, Norway, 7050
Sponsors and Collaborators
Norwegian University of Science and Technology
Investigators
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Principal Investigator: Tom Tørhaug, MD St.Olav's University hospital
Study Chair: Jan Hoff, PhD National Taiwan Normal University
Principal Investigator: Jan Helgerud National Taiwan Normal University
Principal Investigator: Tor Ivar Gjellesvik National Taiwan Normal University
Principal Investigator: Marius Fimland National Taiwan Normal University
Principal Investigator: Per Marius R Moen National Taiwan Normal University
Principal Investigator: Tessa Hill National Taiwan Normal University

Publications of Results:
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Responsible Party: Norwegian University of Science and Technology
ClinicalTrials.gov Identifier: NCT01003353     History of Changes
Other Study ID Numbers: 2009/1241
First Posted: October 28, 2009    Key Record Dates
Last Update Posted: June 25, 2012
Last Verified: June 2012
Keywords provided by Norwegian University of Science and Technology:
Stroke
Strength training
exercise therapy
Additional relevant MeSH terms:
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Stroke
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases