Macular Pigment Optical Density in Healthy Subjects
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|ClinicalTrials.gov Identifier: NCT00993330|
Recruitment Status : Terminated
First Posted : October 12, 2009
Last Update Posted : November 14, 2014
The macular pigment (MP) in humans consists of the yellow, blue-absorbing carotenoids lutein and zeaxanthin, which are contained in vegetables and fruits. The highest concentrations of lutein and zeaxanthin are found in the fovea. Since light entering the eye passes through the MP before reaching the photo receptors it absorbs a significant portion of short-wavelength light. There is evidence that these absorbing properties of the MP as well as the ability of inactivating highly reactive oxygen species are protective for the retina.
Measurement of macular pigment is difficult and the investigators have recently proposed a way of measuring macular pigment optical density (MPOD) based on optical reflectometry. There is increased interest in these measurements in the recent years, because a number of studies has provided evidence that low fruit and vegetable consumption increases the risk of age related macular degeneration (AMD). The present study investigates MP optical density (OD) in healthy volunteers and is used to form a database.
Furthermore the nutritional habits and the influence on MP density will be evaluated.
|Condition or disease|
|Age Related Macular Degeneration|
|Study Type :||Observational|
|Actual Enrollment :||96 participants|
|Official Title:||Macular Pigment Optical Density in Healthy Subjects|
|Study Start Date :||May 2009|
|Actual Primary Completion Date :||September 2010|
|Actual Study Completion Date :||December 2010|
20 healthy subjects between 18 and 40 years
20 healthy subjects between 41 and 50 years
20 healthy subjects between 51 and 60 years
20 healthy subjects between 61 and 70 years
20 healthy subjects between 71 and 80 years
20 healthy subjects between 81 and 90 years
- MPOD as measured with optical reflectometry [ Time Frame: 1 year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00993330
|Department of Clinical Pharmacology, Medical University of Vienna|
|Vienna, Austria, 1090|
|Principal Investigator:||Gerhard Garhofer, MD||Medical University of Vienna|