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S8516-S8736-S9125-S9240 Research Study of Genes in Tissue Samples From Patients With B-cell Non-Hodgkin Lymphoma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00985699
Recruitment Status : Completed
First Posted : September 28, 2009
Last Update Posted : July 24, 2014
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Southwest Oncology Group

Brief Summary:

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at genes in tissue samples from patients with B-cell non-Hodgkin lymphoma.

Condition or disease Intervention/treatment
Lymphoma Genetic: polymorphism analysis Other: laboratory biomarker analysis Other: pharmacogenomic studies

Detailed Description:


  • To determine if toxicity following treatment for lymphoma varies according to genetic polymorphisms in oxidative stress-related genes (i.e., SOD2, CAT, GPX1, GSTM1, and GSTP1).
  • To assess whether these genetic polymorphisms are associated with progression-free survival and/or overall survival in these patients treated for lymphoma.

OUTLINE: Previously collected samples are used for biomarker analysis.

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Study Type : Observational
Actual Enrollment : 337 participants
Time Perspective: Retrospective
Official Title: Pharmacogenomics of Oxidative Stress-Related Genes in Lymphoma
Study Start Date : April 2009
Actual Primary Completion Date : June 2014
Actual Study Completion Date : June 2014

Primary Outcome Measures :
  1. Association of polymorphisms in oxidative stress-related genes with overall survival and/or progression-free survival [ Time Frame: retrospectively ]
  2. Association of polymorphisms in these genes with rate of grade 4-5 hematologic toxicity [ Time Frame: retrospectively ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients enrolled on S8516 S8736 S9125 S9240 consenting to banking


  • Diagnosis of aggressive B-cell non-Hodgkin lymphoma

    • Previously treated with curative intent using anthracycline-based therapies
  • Previously collected paraffin-embedded diagnostic tissues from clinical trials that were collected as part of SWOG treatment protocols (S8516, S8736, S9125, S9240, and S9349) available


  • Not specified


  • See Disease Characteristics

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00985699

Sponsors and Collaborators
Southwest Oncology Group
National Cancer Institute (NCI)
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Study Chair: Margaret M. Briehl, PhD University of Arizona
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Responsible Party: Southwest Oncology Group Identifier: NCT00985699    
Other Study ID Numbers: CDR0000643248
SWOG-S8516-S8736-S9125-S9240-S ( Other Identifier: SWOG )
U10CA032102 ( U.S. NIH Grant/Contract )
First Posted: September 28, 2009    Key Record Dates
Last Update Posted: July 24, 2014
Last Verified: July 2014
Keywords provided by Southwest Oncology Group:
non-Hodgkin lymphoma
cutaneous B-cell non-Hodgkin lymphoma
extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
nodal marginal zone B-cell lymphoma
Additional relevant MeSH terms:
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Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases