Factors Influencing Cardiovascular Prognosis (Pythia-GR)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00973206 |
Recruitment Status :
Not yet recruiting
First Posted : September 9, 2009
Last Update Posted : June 25, 2014
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Condition or disease |
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Cardiovascular Mortality |
Inclusion criteria
- Age > 50 years volunteers (2 towns of 15000 residents one in the north and one in the south of Greece)
- End points
- 5-10 years cardiovascular morbidity and mortality
Measurements at baseline
-
Anthropometrics
- Age (M>55 years; W>65 years)
- Weight-height- BMI
- Abdominal obesity (Waist circumference>102 cm(M), >88cm (W) Family history
- Family history of premature CV disease (M at age<55 years; W at age<65 years)
History
- Smoking
- Diabetes Mellitus,
- Established Heart disease: myocardial infarction; angina; coronary revascularization; heart failure
- Established renal disease [diabetic nephropathy; renal impairment (serum creatinine M>133, W>124 mmol/l); proteinuria (> 300 mg/24 h)]
- Cerebrovascular disease: ischaemic stroke; cerebral haemorrhage; transient ischaemic attack
- Peripheral artery disease
- Advanced retinopathy: haemorrhages or exudates, papilloedema
- Treatment
Measurements
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Measurements Blood pressure
- Clinic BP
- 24h ABPM
- Home BP
Heart
- Electrocardiographic LVH
- Echocardiographic LVH
Vessels
- Carotid wall thickening or plaque
- Carotid-femoral pulse wave velocity
- Ankle/brachial BP index
Lipids or other risk factors
- Total cholesterol, Tg, HDL, LDL
- Plasma creatinine, estimated glomerular filtration rate
- Fasting plasma glucose or postload plasma glucose
- Microalbuminuria and albumin-creatinine ratio
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Glucose tolerance test
- Follow up each 3 year with all the above measurements
Study Type : | Observational |
Estimated Enrollment : | 5000 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Factors Influencing Cardiovascular Prognosis in Hypertensive Patients (Pythia Study) |
Study Start Date : | January 2017 |
Estimated Primary Completion Date : | January 2027 |
Estimated Study Completion Date : | January 2027 |
- Cardiovascular mortality [ Time Frame: 10 years ]
- Hospitalization for CV events [ Time Frame: 10 years ]

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 50 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- All age >50 volunteers
Exclusion Criteria:
- None

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00973206
Contact: Vasilios Kotsis, Prof | 6974748860 ext +30 | vkotsis@auth.gr |
Study Chair: | Vasilios Kotsis, Prof | AUTH |
Responsible Party: | Vasilios Kotsis, Prof. Med, Aristotle University Of Thessaloniki |
ClinicalTrials.gov Identifier: | NCT00973206 |
Other Study ID Numbers: |
AUTH20090609 |
First Posted: | September 9, 2009 Key Record Dates |
Last Update Posted: | June 25, 2014 |
Last Verified: | June 2014 |
cardiovascular morbidity mortality community study |