Gender Differences in Response to Cues in Cocaine Dependence
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|ClinicalTrials.gov Identifier: NCT00969943|
Recruitment Status : Completed
First Posted : September 2, 2009
Last Update Posted : May 7, 2018
The purpose of this study is to evaluate whether men and women respond differently to seeing items related to cocaine use or to remembering stressful events. Four groups of individuals will be recruited to participate in this study: men with cocaine dependence, women with cocaine dependence, men without cocaine dependence, and women without cocaine dependence.
Hypothesis #1: Cocaine-dependent women will demonstrate smaller increases in neuroendocrine, but greater increases in heart rate and more cocaine craving and subjective distress when exposed to stress as compared to cocaine-dependent men and non cocaine-dependent men and women.
Hypothesis #2: Cocaine-dependent men will demonstrate greater increases in neuroendocrine, but greater increases in heart rate and more cocaine craving and subjective distress when exposed to cocaine-related cues as compared to cocaine-dependent women and non cocaine-dependent men and women.
Hypothesis #3: Cocaine-dependent women will demonstrate greater increases in heart rate and more cocaine craving and subjective distress when exposed to stress inducing stimuli as compared to their own responses to a cocaine-related cue.
Hypothesis #4: The neuroendocrine response to a stress hormone (corticotropin releasing hormone; CRH) will be greater in cocaine-dependent women as compared to cocaine-dependent men.
|Condition or disease|
|Study Type :||Observational|
|Official Title:||Gender Differences in Response to Cues in Cocaine Dependence|
|Actual Study Start Date :||March 2003|
|Actual Primary Completion Date :||August 2007|
|Actual Study Completion Date :||August 2007|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00969943
|United States, South Carolina|
|MUSC-Clinical Neurosciences Division|
|Charleston, South Carolina, United States, 29425|