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Adaptive Support Ventilation in the Weaning of COPD

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00969605
Recruitment Status : Completed
First Posted : September 1, 2009
Last Update Posted : May 27, 2010
Sponsor:
Information provided by:
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital

Brief Summary:
Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both as pressure support (PSV) and pressure controlled (PCV) ventilation. Weaning with ASV shows promising results mainly in post-cardiac surgery patients. The aim of this randomized controlled study was to test the hypothesis that weaning with ASV could reduce the weaning duration in patients with chronic obstructive pulmonary disease (COPD) when compared with PSV.

Condition or disease Intervention/treatment Phase
Pulmonary Disease, Chronic Obstructive Procedure: Comparison of two different modes for weaning from mechanical ventilation Phase 4

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 97 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Screening
Official Title: Adaptive Support Ventilation for Faster Weaning in COPD: A Randomized Controlled Trial
Study Start Date : April 2007
Actual Primary Completion Date : May 2008
Actual Study Completion Date : December 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: COPD Lung Diseases

Arm Intervention/treatment
Active Comparator: Pressure support ventilation Procedure: Comparison of two different modes for weaning from mechanical ventilation
Chronic obstructive pulmonary disease patients under mechanical ventilation were randomized to adaptive or pressure support ventilation modes when they met the weaning criteria.
Other Name: weaning protocol

Active Comparator: Adaptive support ventilation Procedure: Comparison of two different modes for weaning from mechanical ventilation
Chronic obstructive pulmonary disease patients under mechanical ventilation were randomized to adaptive or pressure support ventilation modes when they met the weaning criteria.
Other Name: weaning protocol




Primary Outcome Measures :
  1. Weaning duration

Secondary Outcome Measures :
  1. Weaning success
  2. Length of stay in the ICU


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Diagnosis of COPD
  • On invasive mechanical ventilation for at least 24 hours because of hypoxemic and/or hypercapnic respiratory failure

Exclusion Criteria:

  • Mechanical ventilation less then 24 hours (self extubation or death),
  • Having a tracheotomy and
  • COPD coexisted with severe cardiac or neurologic diseases.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00969605


Locations
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Turkey
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit
Izmir, Turkey, 35210
Sponsors and Collaborators
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Investigators
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Study Director: Cenk Kirakli, MD Izmir Dr Suat Seren Chest Diseases and Chest Surgery Education and Research Hospital

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Responsible Party: Cenk Kirakli,MD, Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit
ClinicalTrials.gov Identifier: NCT00969605    
Other Study ID Numbers: IGCEH-ICU-1
First Posted: September 1, 2009    Key Record Dates
Last Update Posted: May 27, 2010
Last Verified: September 2009
Keywords provided by Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital:
weaning
adaptive support ventilation
COPD
Additional relevant MeSH terms:
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Pulmonary Disease, Chronic Obstructive
Lung Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive