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Trends in Intellectual Development in Down Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00954382
Recruitment Status : Unknown
Verified March 2010 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : August 7, 2009
Last Update Posted : March 18, 2010
Information provided by:
National Taiwan University Hospital

Brief Summary:
Previous foreign studies revealed that the IQ in Down syndrome (DS) declines with age, but not any investigation of domestic data in Taiwan was available. Individuals with DS are characterized by limited verbal development, and in this article, authors look into the diverging verbal-nonverbal abilities in the DS phenotype.

Condition or disease
Down Syndrome

Detailed Description:
The present study investigated this by analysis the test results of development /intelligence scales. To compare initial cross-sectional data with longitudinal follow-up, about 12 people with DS were included.

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Study Type : Observational
Estimated Enrollment : 60 participants
Time Perspective: Retrospective
Official Title: Trends in Intellectual Development, and Diverging Verbal and Non-verbal Abilities in the Down Syndrome Phenotype
Study Start Date : May 2009
Estimated Primary Completion Date : December 2009
Estimated Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Down Syndrome

IQ trend
all subjects

Primary Outcome Measures :
  1. IQ [ Time Frame: 2001-2010 ]

Secondary Outcome Measures :
  1. mental age [ Time Frame: 2001-2010 ]

Information from the National Library of Medicine

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Ages Eligible for Study:   3 Months to 40 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Down syndrome

Inclusion Criteria:

  • Down syndrome with psychological test results

Exclusion Criteria:

  • Comorbidity of severe Autism or visual/auditory impairment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00954382

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Contact: Lih-Maan Chang, master +886-2-23123456 ext 67211

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NTUH Recruiting
Taipei, Taiwan, 10041
Contact: Lih-Maan Chang, master    +886-2-23123456 ext 67211   
Principal Investigator: Wuh-Liang Hwu, Ph.D.         
Sponsors and Collaborators
National Taiwan University Hospital
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Principal Investigator: Wuh-Liang Hwu, Ph.D. NTUH

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Responsible Party: Hwu Wuh-Liang, Department of Pediatrics and Medical Genetics, NTUH Identifier: NCT00954382     History of Changes
Other Study ID Numbers: 200904037R
First Posted: August 7, 2009    Key Record Dates
Last Update Posted: March 18, 2010
Last Verified: March 2010
Keywords provided by National Taiwan University Hospital:
Down syndrome
mental age
neuropsychological function
Additional relevant MeSH terms:
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Down Syndrome
Pathologic Processes
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn