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Etiology, Epidemiology and Prognostics of Acute Kidney Injury (AKI)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00953992
Recruitment Status : Completed
First Posted : August 6, 2009
Last Update Posted : August 22, 2019
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Information provided by (Responsible Party):
Feng Ding,MD, Huashan Hospital

Brief Summary:
  • To investigate the etiology, epidemiology and prognostic factors of acute kidney injury.
  • To find out risk factors that relate with the prognosis of acute kidney injury,focusing on inflammation, oxidative stress and nutritional status.
  • To study on the relationship between gene polymorphism and prognosis of acute kidney injury.

Condition or disease
Renal Failure Nutrition Disorders

Detailed Description:
  1. to investigate the relationship between preexisting malnutrition and adverse outcomes in patients with AKI

    - Several nutritional assessment methods such as anthropometric, clinical and biochemical evaluations have been used; however, no single indicator is considered to be a "gold standard."

  2. to evaluate the association of serum nutritional variables and prognosis of acute kidney injury
  3. Given the different half-lives of serum nutritional markers, we hypothesized that the utility of serum nutritional variables as prognostic predictors may differ in early death (<7 days) and late death (>7 days, <28 days) patients.

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Study Type : Observational
Actual Enrollment : 651 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Study of Etiology, Epidemiology and Prognostic Factors of Acute Kidney Injury
Study Start Date : April 2009
Actual Primary Completion Date : December 2018
Actual Study Completion Date : May 2019

Primary Outcome Measures :
  1. renal function survival rate days in the hospital days in the ICU [ Time Frame: discharg from hospital, 28days,90days ]

Biospecimen Retention:   Samples Without DNA
1ml whole blood and 1ml serum will obtained within 24 hour after AKI for hematological and biochemistry analyze.

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 88 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients selected from a university-affiliated hospital in Shanghai, China.

Inclusion Criteria:

  • age >=16 years and <= 88 years
  • clinically diagnosed with acute kidney injury, according RIFLE or KDIGO criteria.

Exclusion Criteria:

  • acute Renal Failure occurring in the setting of burns, obstructive uropathy, allergic interstitial nephritis, acute or rapidly progressive glomerulonephritis, vasculitis, hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura (TTP), malignant hypertension, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, hepatorenal syndrome, cyclosporin or tacrolimus nephrotoxicity
  • Do Not Resuscitate (DNR) status
  • subjects enrolled in another clinical trial that could affect the outcome of this study protocol

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00953992

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Shanghai Ninth People's Hospital
Shanghai, China, 200011
Sponsors and Collaborators
Huashan Hospital
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
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Principal Investigator: Feng Ding, professor Huashan Hospital
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Feng Ding,MD, professor, Huashan Hospital Identifier: NCT00953992    
Other Study ID Numbers: KY2009-107
First Posted: August 6, 2009    Key Record Dates
Last Update Posted: August 22, 2019
Last Verified: August 2019
Keywords provided by Feng Ding,MD, Huashan Hospital:
acute kidney disease
oxidative stress
gene polymorphism
Additional relevant MeSH terms:
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Acute Kidney Injury
Nutrition Disorders
Renal Insufficiency
Kidney Diseases
Urologic Diseases