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Oral Language in Children With Down Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00952354
Recruitment Status : Unknown
Verified August 2009 by University of Sao Paulo.
Recruitment status was:  Active, not recruiting
First Posted : August 6, 2009
Last Update Posted : August 6, 2009
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Information provided by:
University of Sao Paulo

Brief Summary:
The objective of this research is to verify the language of children with Down syndrome concerning lexical, syntactic and semantic aspects using MLU. The hypothesis is that children with Down syndrome will present low performance, regarding not only the quantitative measures as MLU-m, MLU-w, GM-1 and GM-2, but also regarding the qualitative aspects of their production, when compared to children with typical development.

Condition or disease
Down Syndrome

Detailed Description:
One of the alternatives to observe and assess language development and language disorders is to analyze spontaneous language samples, which allos the identification of qualitative and quantitative aspects. The analysis involves the MLU-morphemes, MLU-words and words classes. All words produced are analyzed, including interjections, adverbs and adjectives.Word classes with grammatical characteristics present lower averages, as prepositions and conjunctions. Reference parameters are the ones of the spoken language. The objective assessment with qualitative and quantitative data may help the speech and language pathologist/therapist to determine therapeutic guidelines to each patient.

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Oral Language in Children With Down Syndrome: Lexical, Syntactic and Semantic Aspects
Study Start Date : August 2007
Actual Primary Completion Date : April 2009
Estimated Study Completion Date : August 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Down Syndrome

research group
60 children aged from 3 to 10 years, both genders, observed in a symbolic play situation with their language therapists

Information from the National Library of Medicine

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Ages Eligible for Study:   3 Years to 10 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
60 children with Down syndrome aged from 3 to 10 years

Inclusion Criteria:

  • genetic diagnosis of Down syndrome
  • good health conditions
  • normal results on audiologic evaluation
  • pediatric and ear, nose and throat periodic check ups.
  • attend speech-language therapy at the Speech Language Pathology Laboratory in Syndromes and Sensorimotor Deficits (SLPL-SSD) of the School of Medicine of the University of São Paulo.

Exclusion Criteria:

  • submission to long term hospitalizations due to heart diseases and major respiratory airway infections, that may interfere in the child's global development
  • presence of visual or auditory important deficits

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00952354

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University of Sao Paulo - School of Medicine - Department of Physiotherapy, Communication Sciences and Disorders, Occupational Therapy
Sao Paulo, Brazil, 05360-160
Sponsors and Collaborators
University of Sao Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
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Study Chair: Suelly CO Limongi, PhD University of Sao Paulo
Principal Investigator: Rosangela V Andrade, PhD University of Sao Paulo
Principal Investigator: Fabiola C Flabiano, PhD student University of Sao Paulo
Principal Investigator: Porto Eliza, Ms student University of Sao Paulo
Principal Investigator: Angela MA Carvalho, Ms student University of Sao Paulo

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Suelly Cecilia Olivan Limongi, University of São Paulo Identifier: NCT00952354     History of Changes
Other Study ID Numbers: 473492/2007-5
First Posted: August 6, 2009    Key Record Dates
Last Update Posted: August 6, 2009
Last Verified: August 2009
Keywords provided by University of Sao Paulo:
Down syndrome
language development
language assessment
Additional relevant MeSH terms:
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Down Syndrome
Pathologic Processes
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn