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The Validity of Forced Expiratory Maneuvers in Ataxia Telangiectasia Studied Longitudinally

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00951886
Recruitment Status : Unknown
Verified August 2009 by Sheba Medical Center.
Recruitment status was:  Active, not recruiting
First Posted : August 4, 2009
Last Update Posted : August 4, 2009
Information provided by:
Sheba Medical Center

Brief Summary:

Rationale: Forced spirometry maneuvers are not routinely performed in patients with Ataxia Telangiectasia (A-T), even though they suffer from respiratory illnesses.

Objectives: To study the feasibility and validity of forced spirometry in A-T patients.

Methods: Patients will perform spirometry during clinical visits. Parameters studied will be technical quality, relation to predicted values, age, pulmonary illness, body mass index, mutational status and mutation.

Condition or disease
Ataxia Telangiectasia

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Study Type : Observational
Actual Enrollment : 28 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: The Validity of Forced Expiratory Maneuvers in Ataxia Teleangiectasia Studied Longitudinally
Study Start Date : July 2009
Estimated Study Completion Date : July 2009

Primary Outcome Measures :
  1. spirometry measurements [ Time Frame: 3 years ]

Information from the National Library of Medicine

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Ages Eligible for Study:   3 Years to 20 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with Ataxia Telangiectasia who are followed and treated in the National A-T center at Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel

Inclusion Criteria:

  • Patients with proven Ataxia Telangiectasia

Exclusion Criteria:

  • inability to perform spirometry

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00951886

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Pediatric Pulmonary Unit, The Edmond and Lily Safra Children's Hospital Chaim Sheba Medical Center, Tel HaShomer
Ramat-Gan, Israel, 52621
Sponsors and Collaborators
Sheba Medical Center

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Responsible Party: Sheba medical Center, Ori Efrati, MD, Principal Investigator, Sheba medical Center Identifier: NCT00951886    
Other Study ID Numbers: SHEBA-08-5418-OE-CTIL
First Posted: August 4, 2009    Key Record Dates
Last Update Posted: August 4, 2009
Last Verified: August 2009
Keywords provided by Sheba Medical Center:
Ataxia Teleangiectasia
Respiratory rare diseases
Additional relevant MeSH terms:
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Cerebellar Ataxia
Ataxia Telangiectasia
Spinocerebellar Ataxias
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Cerebellar Diseases
Brain Diseases
Central Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Neurocutaneous Syndromes
Genetic Diseases, Inborn
DNA Repair-Deficiency Disorders
Metabolic Diseases
Immunologic Deficiency Syndromes
Immune System Diseases