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Effects of Glutamine on Gastric Emptying

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00943020
Recruitment Status : Completed
First Posted : July 21, 2009
Last Update Posted : November 17, 2009
Information provided by:
University of Nottingham

Brief Summary:
Surgical patients are usually starved for 8 hours before operation in order to ensure the stomach is empty and thus reduce the chances of vomiting during the anaesthetic. Recent studies have shown that this period of starvation is harmful as it 'weakens' the body before operation. To avoid the harmful effects of starvation, patients are now given carbohydrate (sugar-containing) drinks 2 to 4 hours before surgery. These drinks have been shown to make patients feel better, reduce sickness after the anaesthetic/surgery and result in a quicker recovery from operation. The optimum time of giving these drinks to patients before operation is unknown. Previous studies have shown that the drinks empty from the stomach within 2 - 4 hours depending on their ingredients. The investigators would like to study the effects of adding protein and fat to these drinks on how quickly the drinks empty from the stomach. This study will investigate the hormone responses of the body following intake of 3 different drinks in order to determine the mechanisms that underlie the control of stomach emptying. This information will also allow us to improve the design of these drinks and this could help patients who undergo surgery who receive them.

Condition or disease Intervention/treatment Phase
Starvation Dietary Supplement: Nutricia PreOp nutritional supplement Dietary Supplement: Lipid Dietary Supplement: Glutamine Phase 4

Detailed Description:

The eligibility criteria for this study are as follows:

Interested participants will be asked to attend a screening interview during which the study procedures/risks/benefits will be explained, followed by a brief history and physical examination. If deemed necessary by the study investigator, a 7ml sample of blood will be taken for screening purposes. The volunteer will be deemed eligible for the study once they have passed the screening visit and [when performed] had normal screening blood investigation results.

Each volunteer will be studied 3 times, the order of which will be determined randomly by computer. Participants will report for the study at the Division of GI Surgery (E-floor, West Block, Queen's Medical Centre), at 7:15am. On arrival the subject's height and weight will be recorded and 'drip needle' will will be placed in the back of the wrist. The hand will be rested in a hand-heater allowing venous blood to be sampled.

The subject will be randomly allocated to receive one of the three study drinks. At 7:50am baseline blood will be sampled (10ml [1.5 tablespoons] via the drip needle). At 8am the volunteers will drink the study drink. The rate of stomach emptying will be measured by using Gamma scintigraphy (a specialised medical camera). The drinks will have added a tracer substance that is visible on the camera and allows us to follow drink as it passes through the stomach into the bowels. Each 'picture' of the stomach lasts 20 seconds and we plan to take these every 20 minutes for 4 hours after intake of the drink. At 20 minute intervals (until 220 mins have elapsed) 7ml (1 tablespoon) of blood will be sampled via the drip needle. The final 10 ml blood sample will be taken at 240 minutes following which the drip needle will be removed and the volunteers will be allowed home. The subsequent two studies will be performed 7 days following the first study.

In total 95ml (a sixth of a pint) blood will be taken during each of the 3 crossover studies which will be separated by a period of 7 days (i.e. a total of 285 ml [half a pint] blood will be required from each volunteer).

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 15 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: The Effects of Supplementing Glutamine on the Gastric Emptying Time of a Preoperative Metabolic Conditioning Drink in Healthy Volunteers: a Randomized Crossover Pilot Study
Study Start Date : July 2009
Actual Primary Completion Date : November 2009
Actual Study Completion Date : November 2009

Resource links provided by the National Library of Medicine

Drug Information available for: Glutamine

Arm Intervention/treatment
Active Comparator: Nutricia PreOp + Lipid
Nutricia PreOp + Lipid
Dietary Supplement: Nutricia PreOp nutritional supplement
nutritional supplement

Dietary Supplement: Lipid

Active Comparator: Nutrica PreOP + Glutamine
Nutrica PreOP + Glutamine
Dietary Supplement: Nutricia PreOp nutritional supplement
nutritional supplement

Dietary Supplement: Glutamine

Experimental: Nutricia PreOP
Nutricia PreOP: carbohydrate only drink
Dietary Supplement: Nutricia PreOp nutritional supplement
nutritional supplement

Primary Outcome Measures :
  1. Gastric emptying time following supplementation of a standardised carbohydrate drink with glutamine. [ Time Frame: 4 hours ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy male Caucasian volunteers aged 18-60 years,
  • BMI of 20-25 kg/m2,
  • Able to give voluntary written informed consent to participate in the study,
  • Able to understand the requirements of the study, including anonymous publication, and agree to co-operate with the study procedures.

Exclusion Criteria:

  • Any history of acute or chronic illness,
  • Smoking,
  • Regular medication or substance abuse,
  • Have taken part in any other clinical study within the previous 3 months.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00943020

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United Kingdom
Nottingham Digestive Diseases Centre Biomedical Research Unit
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH
Sponsors and Collaborators
University of Nottingham
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Principal Investigator: Dileep N Lobo, FRCS University of Nottingham
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Mr Dileep N Lobo, University of Nottingham Identifier: NCT00943020    
Other Study ID Numbers: 09026
First Posted: July 21, 2009    Key Record Dates
Last Update Posted: November 17, 2009
Last Verified: November 2009
Keywords provided by University of Nottingham:
Dietary supplement
Carbohydrate loading
Healthy volunteers
Additional relevant MeSH terms:
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Nutrition Disorders