Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00938379|
Recruitment Status : Unknown
Verified July 2009 by London School of Hygiene and Tropical Medicine.
Recruitment status was: Recruiting
First Posted : July 13, 2009
Last Update Posted : July 14, 2009
Rural communities involved in agriculture are often at highest risk of insect-borne diseases in Southeast (SE) Asia.
Skin-applied insect repellents may prove a useful means of reducing mosquito-borne diseases for those people working outdoors in high risk areas.
This trial is evaluating the use of insect repellent (20% diethyltoluamide) to reduce incidence of malaria, Japanese Encephalitis and Dengue. The investigators will recruit up to 1000 households from 100 villages in rural Laos. In each house the investigators shall recruit up to 5 individuals. Half of households will be randomised to repellent, half to a placebo. All individuals will be provided with insecticide treated bed nets for use at night. All household occupants will be followed for 7 months to record malaria cases by Rapid Diagnostic Test every month. Blood spots will be collected at start and end of study to measure Japanese Encephalitis and Dengue. All positive cases will be promptly treated. Outcome will be reduction in number of malaria cases (primary outcome) and Dengue/Japanese Encephalitis (secondary outcomes).
|Condition or disease||Intervention/treatment||Phase|
|Malaria Dengue Japanese Encephalitis||Drug: 20% deet insect repellent Drug: placebo control||Phase 3|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||5000 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Investigator, Outcomes Assessor)|
|Official Title:||Clinical Evaluation of Insect Repellent and Insecticide Treated Nets Against Malaria, JE & Dengue in Rural Communities in Lao PDR|
|Study Start Date :||July 2009|
|Estimated Primary Completion Date :||December 2010|
|Estimated Study Completion Date :||June 2011|
Experimental: 20% deet insect repellent
Drug: 20% deet insect repellent
skin-applied repellent lotion
|Placebo Comparator: lotion without repellent active||
Drug: placebo control
Identical base formulation of lotion but without any deet active
- reduction in malaria incidence [ Time Frame: monthly over 7 months ]
- Reduction in Japanese Encephalitis and / or Dengue infections [ Time Frame: After 7 months intervention ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00938379
|Contact: Vanessa Chen-Hussey, MScfirstname.lastname@example.org|
|Lao People's Democratic Republic|
|Rural villages in Attepu and Sekong Provinces, Laos PDR||Recruiting|
|Pakse, Attepu, Lao People's Democratic Republic|
|Contact: Vanessa Chen-Hussey, MSc 856 (0)21 353 408 ext 116 email@example.com|
|Principal Investigator: Vanessa Chen-Hussey, MSc|
|Principal Investigator:||Nigel Hill, PhD||LSHTM|