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Trial record 11 of 705 for:    region | Chile

Ultra Structure Of Peritoneum At Electronic Microscopy In Control Subjects And Patients With Gastric Cancer

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ClinicalTrials.gov Identifier: NCT00935779
Recruitment Status : Completed
First Posted : July 9, 2009
Last Update Posted : July 9, 2009
Sponsor:
Information provided by:
University of Chile

Brief Summary:
Peritoneal metastases appear in a great proportion of patients affected by gastric carcinoma. Involved mechanisms are poorly understood though experimentally it has been demonstrated that neoplastic cells exfoliated from primary tumor can only implant and proliferate in areas of damaged peritoneum. Objectives: to study ultra-structure of peritoneal surface by electronic microscopy in control subjects and in patients with early or locally advanced gastric cancer looking for spontaneous changes in peritoneal surface not related with surgical injury.

Condition or disease
Stomach Neoplasm

Detailed Description:
18 out of 32 cases were eligible for analysis. Four patients operated on for benign diseases served as control and 14 patients with operable local gastric adenocarcinoma (4 mucosa/submucosa/muscular y 10 serosa lesions) were studied. At the beginning of surgery, a 2 x 2 cm. sample from macroscopically normal visceral peritoneum at mesenterium root was carefully obtained, washed with saline and fixed in glutaraldehyde solution. Besides a sample of peritoneal washing fluid was studied to exclude patients with free cancer cells. Peritoneal tissue was fixed during 24 hours and then all samples were evaluated by electronic microscope.

Study Type : Observational
Actual Enrollment : 18 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Ultra Structure of Peritoneum at Electronic Microscopy in Control Subjects and Patients With Gastric Cancer
Study Start Date : October 2002
Actual Primary Completion Date : July 2004
Actual Study Completion Date : December 2004

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Stomach Cancer

Group/Cohort
Gastric cancer
patients with operable local gastric adenocarcinoma were studied
Control group
patients operated on for benign diseases served as controls, randomly selected among patients with chronic gastro-esophageal reflux disease who were considered good candidates for antireflux surgery and properly matched in sex and age to study group




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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients with operable local gastric adenocarcinoma consulting to Hospital Clinico, University of Chile during study period.
Criteria

Inclusion Criteria:

  • patients with operable local gastric adenocarcinoma

Exclusion Criteria:

  • previous abdominal surgery
  • previous open or blunt abdominal trauma
  • history of inflammatory bowel disease or Typhoid Fever, Gallstone disease, chemotherapy or radiotherapy, or any other abdominal condition that could alter peritoneal integrity.
  • All other gastric malignancies such as lymphomas, GIST, carcinoids

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00935779


Locations
Chile
Department of Surgery, Clinical Hospital, University of Chile
Santiago, Region Metropolitana, Chile
Sponsors and Collaborators
University of Chile
Investigators
Principal Investigator: Patricio Burdiles, MD Department of Surgery, Clinical Hospital, University of Chile

Responsible Party: Patricio Burdiles, Hospital Clinico, Universidad de Chile
ClinicalTrials.gov Identifier: NCT00935779     History of Changes
Other Study ID Numbers: OAIC 043/02
First Posted: July 9, 2009    Key Record Dates
Last Update Posted: July 9, 2009
Last Verified: July 2009

Keywords provided by University of Chile:
Stomach Neoplasms
Peritoneum

Additional relevant MeSH terms:
Stomach Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Stomach Diseases