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A Pilot Study of Migraine and Appetite Behaviour in Children

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00930852
Recruitment Status : Completed
First Posted : July 2, 2009
Last Update Posted : February 22, 2012
University of Liverpool
Information provided by (Responsible Party):
Alder Hey Children's NHS Foundation Trust

Brief Summary:
The purpose of this study is to determine whether there is an association between migraine in children and certain patterns of appetite or eating behaviour that may lead to later obesity.

Condition or disease
Migraine Disorders Obesity

Detailed Description:

Migraine is a chronic neurological disorder characterized by recurrent episodes of headache and associated symptoms. The condition affects approximately 11% of the child population and it can impose considerable burdens on the sufferer either due to the headache itself, or associated co-morbidities such as psychological stress, obesity, sleep problems, etc. Increasing attention is focussing on the shared genetic, environmental and neurobiological mechanisms of migraine co-morbidities to gain further insights into improving outcomes.

We are interested in studying eating behaviours in children with migraine since there is evidence that altered patterns of eating behaviour (and underlying changes in appetite) are seen in migraineurs although not studied systematically. Altered appetite and eating behaviours may be a mechanism for the emerging association between obesity (or degree of adiposity) and migraine severity, detected in both adult and paediatric studies to varying extents. Studying the putative association between migraine, degree of adiposity and patterns of eating behaviour in children may help to tease out causal mechanisms, since both migraine and obesity often evolve over the course of childhood.

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Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Migraine, Appetite Behaviour and Obesity: is There a Link?. A Pilot Study of Migraine and Appetite Behaviour in Children.
Study Start Date : July 2009
Actual Primary Completion Date : August 2010
Actual Study Completion Date : August 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Migraine

Primary Outcome Measures :
  1. Pearson's correlation between PedMIDAS score (measure of migraine severity) and eating behaviour subscale score on the Child Eating Behaviour Questionnaire or Dutch Eating Behaviour Questionnaire.

Secondary Outcome Measures :
  1. Regression coefficient of PedMIDAS score or categories of headache frequency on eating behaviour subscale scores, with covariates of Achenbach Child Behavior Checklist score, current BMI, age, sex, length of history of migraine.
  2. Descriptive analysis of type and severity of typical food cravings and dietary habits using the Food Craving Inventory score and a food intake questionnaire.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   5 Years to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
New referrals to outpatient general paediatric and paediatric neurology service (both accepting primary care referrals) within a single multispecialty children's hospital.

Inclusion Criteria:

  • Children and adolescents between 5 years and 16 years of age.
  • Clinical diagnosis of migraine (for cases).
  • Controls are recruited from children referred with headache, who do not receive diagnosis of migraine.

Exclusion Criteria:

  • Adolescents 17 years or over.
  • Secondary migraine-like disorder e.g., post-craniotomy headache.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00930852

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United Kingdom
Alder Hey Children's Hospital
Liverpool, Merseyside, United Kingdom, L12 2AP
Sponsors and Collaborators
Alder Hey Children's NHS Foundation Trust
University of Liverpool
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Principal Investigator: Ram Kumar, MRCP Alder Hey Children's NHS Foundation Trust
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Responsible Party: Alder Hey Children's NHS Foundation Trust Identifier: NCT00930852    
Other Study ID Numbers: 09/H1017/51
First Posted: July 2, 2009    Key Record Dates
Last Update Posted: February 22, 2012
Last Verified: February 2012
Keywords provided by Alder Hey Children's NHS Foundation Trust:
Primary headache disorders
Feeding Behavior
Additional relevant MeSH terms:
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Migraine Disorders
Nutrition Disorders
Body Weight
Signs and Symptoms
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases